Publication Name	World Journal of Orthopedics
Manuscript ID	26664
Country	Germany

Received	2016-04-21 09:27
Peer-Review Started	2016-04-22 10:08
To Make the First Decision	2016-06-06 10:37
Return for Revision	2016-06-06 15:06
Revised	2016-06-22 18:53
Second Decision	2016-07-08 15:46
Accepted by Journal Editor-in-Chief	2016-07-08 22:22
Accepted by Executive Editor-in-Chief	2016-07-18 10:40
Articles in Press	2016-07-18 10:40
Publication Fee Transferred
Edit the Manuscript by Language Editor	2016-07-21 07:38
Typeset the Manuscript	2016-09-02 11:51
Publish the Manuscript Online	2016-09-12 08:40

ISSN	2218-5836 (online)
Open Access	This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright	© The Author(s) 2016. Published by Baishideng Publishing Group Inc. All rights reserved.
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Category	Orthopedics
Manuscript Type	Systematic Reviews
Article Title	Biologic agents for anterior cruciate ligament healing: A systematic review
Manuscript Source	Invited Manuscript
All Author List	Berardo Di Matteo, Markus Loibl, Luca Andriolo, Giuseppe Filardo, Johannes Zellner, Matthias Koch and Peter Angele
Funding Agency and Grant Number
Corresponding Author	Berardo Di Matteo, MD, Ⅰ Orthopaedic and Traumatologic Clinic - Biomechanics and Technology Inno­vation Laboratory, Rizzoli Orthopaedic Institute, Via Pupilli n. 1, 40136 Bologna, Italy. berardo.dimatteo@gmail.com
Key Words	Platelet-rich plasma; Growth factors; Stem cells; Anterior cruciate ligament reconstruction; Anterior cruciate ligament repair; Anterior cruciate ligament healing; Sports medicine; Regenerative medicine
Core Tip	There has been a growing interest in the past years on regenerative approaches to stimulate healing of musculo-skeletal tissues. The present systematic review focuses on the clinical application of biologic agents [platelet-rich plasma (PRP) and stem cells] to favor anterior cruciate ligament healing during proce-dures of reconstruction or repair. We show that there is inconclusive evidence to support the use of biologic augmentations, also due to the paucity of trials currently available, especially concerning stem cells. Looking at PRP, positive findings in terms of promotion of graft maturation were documented, but no beneficial influence was observed in terms of clinical outcome, bone-graft integration and prevention of tunnel enlargement.
Publish Date	2016-09-12 08:40
Citation	Di Matteo B, Loibl M, Andriolo L, Filardo G, Zellner J, Koch M, Angele P. Biologic agents for anterior cruciate ligament healing: a systematic review. World J Orthop 2016; 7(9): 592-603
URL	http://www.wjgnet.com/2218-5836/full/v7/i9/592.htm
DOI	http://dx.doi.org/10.5312/wjo.v7.i9.592

Full Article (PDF)	WJO-7-592.pdf
Full Article (Word)	WJO-7-592.doc
Manuscript File	26664-Review.docx
Answering Reviewers	26664-Answering reviewers.pdf
Audio Core Tip	26664-Audio core tip.mp3
Biostatistics Review Certificate	26664-Biostatistics statement.pdf
Conflict-of-Interest Disclosure Form	26664-Conflict-of-interest statement.pdf
Copyright License Agreement	26664-Copyright assignment.pdf
Peer-review Report	26664-Peer review(s).pdf
Journal Editor-in-Chief Review Report	26664-Journal editor-in-chief review report.pdf
Scientific Misconduct Check	26664-Scientific misconduct check.pdf
Scientific Editor Work List	26664-Scientific editor work list.pdf