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Articles Published Processes
8/23/2016 6:33:00 PM | Browse: 993 | Download: 2251
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Received |
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2016-04-23 15:25 |
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Peer-Review Started |
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2016-04-23 17:02 |
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To Make the First Decision |
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2016-05-27 14:57 |
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Return for Revision |
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2016-05-28 13:59 |
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Revised |
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2016-06-11 08:45 |
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Second Decision |
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2016-06-28 09:04 |
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Accepted by Journal Editor-in-Chief |
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Accepted by Executive Editor-in-Chief |
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2016-07-06 18:33 |
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Articles in Press |
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2016-07-06 18:33 |
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Publication Fee Transferred |
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Edit the Manuscript by Language Editor |
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2016-07-12 23:51 |
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Typeset the Manuscript |
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2016-08-05 15:47 |
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Publish the Manuscript Online |
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2016-08-24 10:09 |
| ISSN |
1007-9327 (print) and 2219-2840 (online) |
| Open Access |
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2016. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Gastroenterology & Hepatology |
| Manuscript Type |
Basic Study |
| Article Title |
Synergistic anticancer effect of exogenous wild-type p53 gene combined with 5-FU in human colon cancer resistant to 5-FU in vivo
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| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Qi Xie, Min-Yi Wu, Ding-Xuan Zhang, Yi-Ming Yang, Bao-Shuai Wang, Jing Zhang, Jin Xu, Wei-De Zhong and Jia-Ni Hu |
| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| Natural Science Foundation of Guangdong |
2015A030313732 |
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| Corresponding Author |
Qi Xie, MD, Medical Imaging Department, Nansha Central Hospital, Guangzhou First People’s Hospital, Guangzhou Medical University, Guangzhou 511457, Guangdong Province, China. xieqi8@yeah.net |
| Key Words |
Human colon cancer; Multidrug resistance; 5-Fluorouracil; Recombinant adenovirus-mediated p53; Xenografts in nude mice |
| Core Tip |
To observe anticancer action of a recombinant adenovirus-mediated p53 (rAd-p53) combined with 5-fluorouracil (5-FU) in human colon cancer with resistance to 5-FU in vivo to investigate the potential and mechanism of rAd-p53 in the reversal of resistance to 5-FU in human colon cancer. Our previous results revealed that exogenous wild-type p53 gene from rAd-p53 can decrease expression of PKC, P-gp and MRP1 in SW480/5-FU (5-FU resistance) and promote apoptosis of tumor cell, which contributes to reversing 5-FU resistance in vivo. 5-FU can increase the expression of exogenous wild-type p53, so 5-FU combined with rAd-p53 has a synergistic anticancer effect for colon cancer of 5-FU resistance in vivo. |
| Publish Date |
2016-08-24 10:09 |
| Citation |
Xie Q, Wu MY, Zhang DX, Yang YM, Wang BS, Zhang J, Xu J, Zhong WD, Hu JN. Synergistic anticancer effect of exogenous wild-type p53 gene combined with 5-FU in human colon cancer resistant to 5-FU in vivo. World J Gastroenterol 2016; 22(32): 7342-7352 |
| URL |
http://www.wjgnet.com/1007-9327/full/v22/i32/7342.htm |
| DOI |
http://dx.doi.org/10.3748/wjg.v22.i32.7342 |
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