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8/29/2014 6:42:00 PM | Browse: 413 | Download: 266
Publication Name World Journal of Clinical Cases
Manuscript ID 2678
Country/Territory United States
Received
2013-03-06 20:58
Peer-Review Started
2013-03-07 15:15
To Make the First Decision
2013-03-25 15:16
Return for Revision
2013-03-28 17:09
Revised
2013-04-02 08:21
Second Decision
2013-05-07 17:42
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief
2013-05-08 09:25
Articles in Press
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript
2013-06-05 21:21
Publish the Manuscript Online
2013-06-14 17:45
ISSN 2307-8960 (online)
Open Access
Copyright
Article Reprints For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
Permissions For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website http://www.wjgnet.com
Category Oncology
Manuscript Type Review
Article Title Monitoring photodynamic therapy of head and neck malignancies with optical spectroscopies
Manuscript Source Invited Manuscript
All Author List Ulas Sunar
Funding Agency and Grant Number
Funding Agency Grant Number
RPCI Startup P30CA16056
NCI CA55791
Corresponding author Ulas Sunar, PhD, Department of Cell Stress Biology and Oncology, PDT Center, Roswell Park Cancer Institute, Elm and Carlton Streets, Buffalo, NY 14263, United States. ulas.sunar@roswellpark.org
Keywords Head and neck cancer; Photodynamic therapy; Monitoring and predicting response; Blood flow; Oxygenation; Oxygen metabolism; Diffuse optical imaging
Core Tip Most treatment approaches including chemo-radiation and surgery can induce prolonged morbidity and functional loss resulting in severe impairment of patients’ quality of life. Photodynamic therapy (PDT) is an emerging alternative treatment option without any significant accumulative side effects due to targeted light illumination and preferential accumulation of photosensitizers (PSs). However, PDT has not found widespread applications at the clinic mainly due to variable responses that originated from unstandardized treatment protocols such as different light and PS doses. Novel optical imaging techniques can quantify PDT-dosimetry related parameters such as local light and PS dose in tissue and PDT response related parameters such as tissue oxygenation and blood flow noninvasively without any contrast agent administration, thereby providing real-time feedback about the treatment efficacy for optimizing and standardizing PDT.
Publish Date 2013-06-14 17:45
Citation Sunar U. Monitoring photodynamic therapy of head and neck malignancies with optical spectroscopies. World J Clin Cases 2013; 1(3): 96-105
Url http://www.wjgnet.com/2307-8960/full/v1/i3/96.htm
DOI http://dx.doi.org/10.12998/wjcc.v1.i3.96
Full Article (PDF) WJCC-1-96.pdf
Manuscript File 2678-Review.docx
Answering Reviewers 2678-Answering reviewers.docx
Copyright License Agreement 2678-Copyright assignment.pdf
Peer-review Report 2678-Peer review(s).pdf
Scientific Editor Work List 2678-Scientific editor work list.doc