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Articles Published Processes
1/22/2017 8:28:00 AM | Browse: 1091 | Download: 1611
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Received |
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2016-04-26 10:45 |
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Peer-Review Started |
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2016-04-26 16:29 |
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To Make the First Decision |
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2016-07-20 16:50 |
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Return for Revision |
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2016-10-21 09:15 |
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Revised |
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2016-10-25 04:53 |
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Second Decision |
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2016-12-07 16:33 |
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Accepted by Journal Editor-in-Chief |
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Accepted by Executive Editor-in-Chief |
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2016-12-14 16:35 |
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Articles in Press |
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2016-12-14 16:36 |
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Publication Fee Transferred |
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Edit the Manuscript by Language Editor |
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Typeset the Manuscript |
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2017-01-11 08:37 |
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Publish the Manuscript Online |
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2017-01-22 08:28 |
| ISSN |
1948-5182 (online) |
| Open Access |
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2017. Published by Baishideng Publishing Group Inc. All rights reserved.
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| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Gastroenterology & Hepatology |
| Manuscript Type |
Retrospective Cohort Study |
| Article Title |
Advanced non-alcoholic steatohepatitis cirrhosis: A high-risk population for pre-liver transplant portal vein thrombosis
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| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Jonathan G Stine, Curtis K Argo, Shawn J Pelletier, Daniel G Maluf, Stephen H Caldwell and Patrick G Northup |
| Funding Agency and Grant Number |
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| Corresponding Author |
Patrick G Northup, MD, MHS, Division of Gastroenterology and Hepatology, Department of Medicine, Center for the Study of Coagulation Disorders in Liver Disease, University of Virginia, JPA and Lee Street, MSB 2145, PO Box 800708, Charlottesville, VA 22908-0708,
United States. northup@virginia.edu |
| Key Words |
Liver transplantation; Non-alcoholic fatty liver disease; Portal hypertension; Hepatology; Coagulopathy |
| Core Tip |
Non-alcoholic steatohepatitis (NASH) is in-creasing in prevalence and is expected to be the leading indication for liver transplantation in the foreseeable future. There is a growing body of evidence supporting the clinical importance of a thrombophilic state in patients with NASH. In NASH patients, the most severe hypercoagulable environment is found in patients with NASH cirrhosis. High-risk NASH patients (concomitant age > 60 years, obesity, diabetes and hypertension) have inferior post transplantation outcomes, however, how this group’s risk of clotting compares to other etio-logies of liver disease is unknown. In a retrospective nationwide United States based cohort, we provide further evidence of coagulation derangement in NASH and identify a new high-risk subtype in the high-risk NASH population. Whether or not this high-risk group may benefit from preventative anticoagulation remains unknown. |
| Publish Date |
2017-01-22 08:28 |
| Citation |
Stine JG, Argo CK, Pelletier SJ, Maluf DG, Caldwell SH, Northup PG. Advanced non-alcoholic steatohepatitis cirrhosis: A high-risk population for pre-liver transplant portal vein thrombosis. World J Hepatol 2017; 9(3): 139-146 |
| URL |
http://www.wjgnet.com/1948-5182/full/v9/i3/139.htm |
| DOI |
http://dx.doi.org/10.4254/wjh.v9.i3.139 |
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