| Category |
Gastroenterology & Hepatology |
| Manuscript Type |
Autobiography |
| Article Title |
Pink-color sign in esophageal squamous neoplasia, and speculation regarding the underlying mechanism
|
| Manuscript Source |
Invited Manuscript |
| All Author List |
Ryu Ishihara, Hiromitsu Kanzaki, Hiroyasu Iishi, Kengo Nagai, Fumi Matsui, Takeshi Yamashina, Noriko Matsuura, Takashi Ito, Mototsugu Fujii, Sachiko Yamamoto, Noboru Hanaoka, Yoji Takeuchi, Koji Higashino, Noriya Uedo, Masaharu Tatsuta, Yasuhiko Tomita and Shingo Ishiguro |
| Funding Agency and Grant Number |
|
| Corresponding Author |
Ryu Ishihara, MD, Department of Gastrointestinal Oncology, Osaka Medical Center for Cancer and Cardiovascular Diseases, 3-3, Nakamichi 1-chome, Higashinari-ku, Osaka 537-8511, Japan. isihara-ry@mc.pref.osaka.jp
|
| Key Words |
Chromoendoscopy; Esophageal cancer; Esophageal squamous neoplasia; Iodine staining; Pink-color sign |
| Core Tip |
The pink-color sign of iodine-unstained lesions is useful for the diagnosis of esophageal squamous cell carcinoma. We investigated histologic findings of esophageal neoplasms, and found that absence of the keratinous layer because of neoplastic cell proliferation may be responsible for the pink-color sign. Quantitative analysis of color showed that pink-color sign positive mucosa underwent early color fading from the color of the iodine (yellow) to the color of the mucosa (pink) within 2-3 min. Based on these results, we speculated on the mechanism underlying the pink-color sign. These findings may improve our understanding of the characteristics of esophageal neoplasms.
|
| Publish Date |
2013-07-20 20:47 |
| Citation |
Ishihara R, Kanzaki H, Iishi H, Nagai K, Matsui F, Yamashina T, Matsuura N, Ito T, Fujii M, Yamamoto S, Hanaoka N, Takeuchi Y, Higashino K, Uedo N, Tatsuta M, Tomita Y, Ishiguro S. Pink-color sign in esophageal squamous neoplasia, and speculation regarding the underlying mechanism. World J Gastroenterol 2013; 19(27): 4300-4308 |
| URL |
http://www.wjgnet.com/1007-9327/full/v19/i27/4300.htm |
| DOI |
http://dx.doi.org/10.3748/wjg.v19.i27.4300 |
