Publication Name	World Journal of Clinical Cases
Manuscript ID	26926
Country	Canada

Received	2016-04-29 15:39
Peer-Review Started	2016-05-03 10:41
To Make the First Decision	2016-07-04 15:41
Return for Revision	2016-07-05 20:10
Revised	2016-07-18 07:48
Second Decision	2016-07-28 14:51
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief	2016-08-08 14:33
Articles in Press	2016-08-08 14:33
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2016-10-08 17:18
Publish the Manuscript Online	2016-10-14 10:12

ISSN	2307-8960 (online)
Open Access	This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright	© The Author(s) 2016. Published by Baishideng Publishing Group Inc. All rights reserved.
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Category	Oncology
Manuscript Type	Case Report
Article Title	Long-term stabilization of stage 4 colon cancer using sodium dichloroacetate therapy
Manuscript Source	Invited Manuscript
All Author List	Akbar Khan, Douglas Andrews and Anneke C Blackburn
Funding Agency and Grant Number
Corresponding Author	Akbar Khan, MD, Medical Director, Medicor Cancer Centres Inc., 4576 Yonge St., Suite 301, Toronto, ON M2N 6N4, Canada. akhan@medicorcancer.com
Key Words	Dichloroacetate; Cancer; Colon; Colorectal; Cytostatic; Stabilization; Growth inhibition; Intravenous
Core Tip	Oral dichloroacetate sodium (DCA) has been investigated as a novel metabolic therapy for various cancers. Response to therapy in human studies is measured by standard response evaluation criteria for solid tumours definitions, which define “response” by the degree of tumour reduction, or tumour disap-pearance on imaging. However, DCA can also act as a cytostatic agent, without causing apoptosis (program-med cell death). A case is presented in which oral DCA therapy resulted in tumour stabilization of stage 4 colon cancer in a 57 years old female for a period of nearly 4 years, with no serious toxicity.
Publish Date	2016-10-14 10:12
Citation	Khan A, Andrews D, Blackburn AC. Long-term stabilization of stage 4 colon cancer using sodium dichloroacetate therapy. World J Clin Cases 2016; 4(10): 336-343
URL	http://www.wjgnet.com/2307-8960/full/v4/i10/336.htm
DOI	http://dx.doi.org/10.12998/wjcc.v4.i10.336

Full Article (PDF)	WJCC-4-336.pdf
Full Article (Word)	WJCC-4-336.doc
Manuscript File	26926-Review.docx
Answering Reviewers	26926-Answering reviewers.pdf
Audio Core Tip	26926-Audio core tip.mp3
Conflict-of-Interest Disclosure Form	26926-Conflict-of-interest statement.pdf
Copyright License Agreement	26926-Copyright assignment.pdf
Signed Informed Consent Form(s) or Document(s)	Informed_Consent_Statement_20160429141110.docx
Institutional Review Board Approval Form or Document	26926-Institutional review board statement.pdf
Peer-review Report	26926-Peer-review(s).pdf
Scientific Misconduct Check	26926-Scientific misconduct check.pdf
Scientific Editor Work List	26926-Scientific editor work list.pdf