Publication Name	World Journal of Nephrology
Manuscript ID	26955
Country	Italy

Received	2016-05-02 18:04
Peer-Review Started	2016-05-03 14:36
To Make the First Decision	2016-07-04 15:41
Return for Revision	2016-07-06 08:17
Revised	2016-08-02 01:47
Second Decision	2016-08-08 15:31
Accepted by Journal Editor-in-Chief	2016-08-08 17:46
Accepted by Executive Editor-in-Chief	2016-08-18 11:55
Articles in Press	2016-08-18 11:55
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2016-08-26 15:37
Publish the Manuscript Online	2016-09-01 09:16

ISSN	2220-6124 (online)
Open Access	This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
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Category	Urology & Nephrology
Manuscript Type	Minireviews
Article Title	Carbon dioxide: Global warning for nephrologists
Manuscript Source	Invited Manuscript
All Author List	Marco Marano, Anna D’Amato and Alessandra Cantone
Funding Agency and Grant Number
Corresponding Author	Marco Marano, MD, Hemodialysis Unit, Maria Rosaria Clinic, via Colle San Bartolomeo, 50, Pompeii, 80045 Naples, Italy. marano965@gmail.com
Key Words	Acid-base assessment; Bicarbonate; Carbon dioxide; Hemodialysis; Metabolic acidosis; Mixed disorders; Ventilatory response; Expected pressure of carbon dioxide; Vascular access recirculation
Core Tip	Partial pressure of carbon dioxide (pCO2) should be always taken into account for comprehensive assessment of acid-base imbalances of hemodialysis patients, also because respiratory disorders are very common in this population. To infer a respiratory disorder superimposing to metabolic acidosis, nephrologists should compute the expected pCO2 complying with the reduced bicarbonate concentration. Moreover, they have to take in account CO2 load from dialysis solution, because this burden may be harmful if ventilatory compensation does not properly occur. Finally, checking an increase of pCO2 in arterial line of extracorporeal circuit is an easy and reliable method to discover vascular access recirculation.
Publish Date	2016-09-01 09:16
Citation	Marano M, D’Amato A, Cantone A. Carbon dioxide: Global warning for nephrologists. World J Nephrol 2016; 5(5): 429-436
URL	http://www.wjgnet.com/2220-6124/full/v5/i5/429.htm
DOI	http://dx.doi.org/10.5527/wjn.v5.i5.429

Full Article (PDF)	WJN-5-429.pdf
Full Article (Word)	WJN-5-429.doc
Manuscript File	26955-Review.docx
Answering Reviewers	26955-Answering reviewers.pdf
Audio Core Tip	26955-Audio core tip.mp3
Conflict-of-Interest Disclosure Form	26955-Conflict-of-interest statement.pdf
Copyright License Agreement	26955-Copyright assignment.pdf
Signed Informed Consent Form(s) or Document(s)	Informed_Consent_Statement_20160430222012.docx
Supplementary Material	Supplementary_Material_20160430222304.pdf
Peer-review Report	26955-Peer-review(s).pdf
Journal Editor-in-Chief Review Report	26955-Journal editor-in-chief review report.pdf
Scientific Misconduct Check	26955-Scientific misconduct check.pdf
Scientific Editor Work List	26955-Scientific editor work list.pdf