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7/4/2016 2:42:00 PM | Browse: 422 | Download: 509
Publication Name World Journal of Gastroenterology
Manuscript ID 27006
Country of Manuscript Source Canada
Received
2016-05-04 08:58
Peer-Review Started
2016-05-04 15:42
To Make the First Decision
2016-05-27 11:09
Return for Revision
2016-05-27 15:38
Revised
2016-05-31 02:13
Second Decision
2016-06-02 10:15
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief
2016-06-13 18:14
Articles in Press
2016-06-13 18:14
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript
2016-06-26 17:00
Publish the Manuscript Online
2016-07-04 14:42
ISSN 1007-9327 (print) and 2219-2840 (online)
Open Access This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright © The Author(s) 2016. Published by Baishideng Publishing Group Inc. All rights reserved.
Article Reprints For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
Permissions For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website http://www.wjgnet.com
Specialty Infectious Diseases
Manuscript Type Editorial
Article Title Symbiotic chemo- and immuno-therapy for hepatitis B and C viruses
Manuscript Source Invited Manuscript
All Author List Babita Agrawal and Rakesh Kumar
Funding Agency and Grant Number
Corresponding author Dr. Rakesh Kumar, Professor, Depart­ment of Laboratory Medicine and Pathology, Faculty of Medicine and Dentistry, University of Alberta, 116 St and 85 Ave, Edmonton, AB T6G 2R3, Canada. rkumar@ualberta.ca
Keywords Hepatitis C virus; Hepatitis B virus; Direct-acting antiviral; Chemotherapy; Immunotherapy
Core Tip Immune related mechanisms have been shown to eliminate both Hepatitis B and C viruses (HBV and HCV) from chronically infected host cells via non-cytolytic mechanisms. Current direct-acting antivirals against replication of both HBV and HCV are effective and provide significant viral suppression in a relatively short period of time. This time window should be harnessed to target host-mediated immune mechanisms to clear the host of the infection. This strategy would lead to a significant reduction in cost, duration, side effects and development of resistance associated with direct-acting antivirals therapy. In summary, regimens combining chemo- and immuno-therapy must be used in a mutually beneficial manner to eradicate HBV and/or HCV from a host.
Publish Date 2016-07-04 14:42
Citation Agrawal B, Kumar R. Symbiotic chemo- and immuno-therapy for hepatitis B and C viruses. World J Gastroenterol 2016; 22(25): 5623-5626
Url http://www.wjgnet.com/1007-9327/full/v22/i25/5623.htm
DOI http://dx.doi.org/10.3748/wjg.v22.i25.5623
Full Article (PDF) WJG-22-5623.pdf
Full Article (Word) WJG-22-5623.doc
Manuscript File 27006-Reveiw.docx
Answering Reviewers 27006-Answering reviewers.pdf
Audio Core Tip 27006-Audio core tip.aif
Conflict-of-Interest Disclosure Form 27006-Conflict-of-interest statement.pdf
Copyright License Agreement 27006-Copyright assignment.pdf
Peer-review Report 27006-Peer-review(s).pdf
Scientific Misconduct Check 27006-Scientific misconduct check.pdf
Scientific Editor Work List 27006-Scientific editor work list.pdf