Publication Name	World Journal of Gastroenterology
Manuscript ID	27036
Country	Australia

Received	2016-05-06 09:42
Peer-Review Started	2016-05-06 11:46
To Make the First Decision	2016-06-20 10:51
Return for Revision	2016-06-27 17:02
Revised	2016-07-22 21:36
Second Decision	2016-08-05 10:17
Accepted by Journal Editor-in-Chief	2016-08-06 09:27
Accepted by Executive Editor-in-Chief	2016-08-10 15:46
Articles in Press	2016-08-10 15:46
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2016-09-06 17:43
Publish the Manuscript Online	2016-09-14 19:04

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access	This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright	© The Author(s) 2016. Published by Baishideng Publishing Group Inc. All rights reserved.
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Website	http://www.wjgnet.com

Category	Gastroenterology & Hepatology
Manuscript Type	Basic Study
Article Title	Dietary advanced glycation end-products aggravate non-alcoholic fatty liver disease
Manuscript Source	Invited Manuscript
All Author List	Christopher Leung, Chandana B Herath, Zhiyuan Jia, Sof Andrikopoulos, Bronwyn E Brown, Michael J Davies, Leni R Rivera, John B Furness, Josephine M Forbes and Peter W Angus
Funding Agency and Grant Number	Funding Agency Grant Number National Health and Medical Research Council of Australia 1029990
Corresponding Author	Christopher Leung, MBBS, FRACP, Department of Gastroenterology and Hepatology, Austin Health, Austin Hospital, 145 Studley Rd, Heidelberg, Victoria 3084, Australia. chris.leung@y7mail.com
Key Words	Advanced glycation end-products; Fructose; Steatohepatitis; Non-alcoholic fatty liver disease; Hepatic fibrosis; Oxidative stress
Core Tip	A novel high fructose, high cholesterol diet produces hepatic non-alcoholic steatohepatitis (NASH) with fibrosis in 33 wk and increasing the Advanced glycation end products (AGEs), content of this diet via baking increases hepatic fibrosis whilst vinegar marination decreases dietary AGE levels, abrogating the harmful effects of AGEs. RAGE-/- animals appeared to be protected from the additional harmful effects of a high AGE containing diet suggesting the central role of RAGE in progression of NASH. Increased cell proliferation and oxidative stress in isolated primary Kupffer cells with the addition of AGEs suggests they are an important mechanism in which AGEs contribute to liver injury.
Publish Date	2016-09-14 19:04
Citation	Leung C, Herath CB, Jia Z, Andrikopoulos S, Brown BE, Davies MJ, Rivera LR, Furness JB, Forbes JM, Angus PW. Dietary advanced glycation end-products aggravate non-alcoholic fatty liver disease. World J Gastroenterol 2016; 22(35): 8026-8040
URL	http://www.wjgnet.com/1007-9327/full/v22/i35/8026.htm
DOI	http://dx.doi.org/10.3748/wjg.v22.i35.8026

Full Article (PDF)	WJG-22-8026.pdf
Full Article (Word)	WJG-22-8026.doc
Manuscript File	27036-Review.docx
Answering Reviewers	27036-Answering reviewers.pdf
Audio Core Tip	27036-Audio core tip.mp3
Biostatistics Review Certificate	27036-Biostatistics statement.pdf
Conflict-of-Interest Disclosure Form	27036-Conflict-of-interest statement.pdf
Copyright License Agreement	27036-Copyright assignment.pdf
Approved Grant Application Form(s) or Funding Agency Copy of any Approval Document(s)	27036-Grant application form(s).pdf
Institutional Animal Care and Use Committee Approval Form or Document	27036-Institutional animal care and use committee statement.pdf
Institutional Review Board Approval Form or Document	27036-Institutional review board statement.pdf
Supplementary Material	27036-Supplementary material.pdf
Peer-review Report	27036-Peer-review(s).pdf
Journal Editor-in-Chief Review Report	27036-Journal editor-in-chief review report.pdf
Scientific Misconduct Check	27036-Scientific misconduct check.pdf
Scientific Editor Work List	27036-Scientific editor work list.pdf