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10/25/2016 8:46:00 AM | Browse: 1373 | Download: 1982
Publication Name World Journal of Hepatology
Manuscript ID 27057
Country/Territory Israel
Received
2016-05-08 13:37
Peer-Review Started
2016-05-09 20:16
To Make the First Decision
2016-06-06 11:05
Return for Revision
2016-06-13 16:40
Revised
2016-07-18 00:00
Second Decision
2016-08-30 11:56
Accepted by Journal Editor-in-Chief
2016-08-30 20:34
Accepted by Company Editor-in-Chief
2016-09-18 14:48
Articles in Press
2016-09-18 14:48
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript
2016-10-18 14:37
Publish the Manuscript Online
2016-10-25 08:46
ISSN 1948-5182 (online)
Open Access This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright © The Author(s) 2016. Published by Baishideng Publishing Group Inc. All rights reserved.
Article Reprints For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
Permissions For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website http://www.wjgnet.com
Category Virology
Manuscript Type Retrospective Study
Article Title Retrospective study of the associations between hepatitis C virus infection and metabolic factors
Manuscript Source Unsolicited Manuscript
All Author List Shira Yair-Sabag, Elchanan Nussinson, Ofir Ben-Assuli, Fahmi Shibli, Azmi Shahbari and Shira Zelber-Sagi
Funding Agency and Grant Number
Corresponding Author Elchanan Nussinson, MD, Gastro­enterology Institute, Emek Medical Center, Duchifat 7 St, Afula 18742, Israel. elchanann@gmail.com
Key Words Hepatitis C virus; Type 2 diabetes mellitus; Antiviral therapy; Sustained viral response; Metabolic syndrome; Hepatic steatosis; Peg interferon alpha; Ribavirin; Direct acting antiviral agents
Core Tip Hepatitis C virus (HCV) is associated with a unique metabolic syndrome (MS) type: Insulin resistance with type 2 diabetes mellitus (T2DM), hypocho-lesterolemia, and liver steatosis. We retrospectively investigated the association between MS components and HCV infection, including antiviral therapy response, for 119 patients infected with HCV treated with inter-feron alpha and ribavirin. After long-term follow-up, de novo T2DM incidence significantly decreased, and triglyceride levels significantly increased in treatment responders. Only steatosis tended to affect treatment response. The association between HCV and lipid metabolic pathways may be important even with new direct antiviral agents. Patients infected with HCV should be screened for T2DM.
Publish Date 2016-10-25 08:46
Citation Yair-Sabag S, Nussinson E, Ben-Assuli O, Shibli F, Shahbari A, Zelber-Sagi S. Retrospective study of the associations between hepatitis C virus infection and metabolic factors. World J Hepatol 2016; 8(30): 1269-1278
URL http://www.wjgnet.com/1948-5182/full/v8/i30/1269.htm
DOI http://dx.doi.org/10.4254/wjh.v8.i30.1269
Full Article (PDF) WJH-8-1269.pdf
Full Article (Word) WJH-8-1269.doc
Manuscript File 27057-Review.doc
Answering Reviewers 27057-Answering reviewers.pdf
Audio Core Tip 27057-Audio core tip.mp3
Biostatistics Review Certificate Biostatistics_Statement_20160507002558.docx
Conflict-of-Interest Disclosure Form 27057-Conflict-of-interest statement.pdf
Copyright License Agreement 27057-Copyright assignment.pdf
Signed Informed Consent Form(s) or Document(s) Informed_Consent_Statement_20160507002606.docx
Institutional Review Board Approval Form or Document 27057-Institutional review board statement.pdf
Non-Native Speakers of English Editing Certificate 27057-Language certificate.pdf
Peer-review Report 27057-Peer-review(s).pdf
Journal Editor-in-Chief Review Report 27057-Journal editor-in-chief review report.pdf
Scientific Misconduct Check 27057-Scientific misconduct check.pdf
Scientific Editor Work List 27057-Scientific editor work list.pdf