Publication Name	World Journal of Hepatology
Manuscript ID	27057
Country	Israel

Received	2016-05-08 13:37
Peer-Review Started	2016-05-09 20:16
First Decision by Editorial Office Director
Return for Revision	2016-06-13 16:40
Revised	2016-07-18 00:00
Publication Fee Transferred
Second Decision by Editor	2016-08-30 11:56
Second Decision by Editor-in-Chief	2016-08-30 20:34
Final Decision by Editorial Office Director	2016-09-18 14:48
Articles in Press	2016-09-18 14:48
Edit the Manuscript by Language Editor
Typeset the Manuscript	2016-10-18 14:37
Publish the Manuscript Online	2016-10-25 08:46

ISSN	1948-5182 (online)
Open Access	This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright	© The Author(s) 2016. Published by Baishideng Publishing Group Inc. All rights reserved.
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Category	Virology
Manuscript Type	Retrospective Study
Article Title	Retrospective study of the associations between hepatitis C virus infection and metabolic factors
Manuscript Source	Unsolicited Manuscript
All Author List	Shira Yair-Sabag, Elchanan Nussinson, Ofir Ben-Assuli, Fahmi Shibli, Azmi Shahbari and Shira Zelber-Sagi
Funding Agency and Grant Number
Corresponding Author	Elchanan Nussinson, MD, Gastro­enterology Institute, Emek Medical Center, Duchifat 7 St, Afula 18742, Israel. elchanann@gmail.com
Key Words	Hepatitis C virus; Type 2 diabetes mellitus; Antiviral therapy; Sustained viral response; Metabolic syndrome; Hepatic steatosis; Peg interferon alpha; Ribavirin; Direct acting antiviral agents
Core Tip	Hepatitis C virus (HCV) is associated with a unique metabolic syndrome (MS) type: Insulin resistance with type 2 diabetes mellitus (T2DM), hypocho-lesterolemia, and liver steatosis. We retrospectively investigated the association between MS components and HCV infection, including antiviral therapy response, for 119 patients infected with HCV treated with inter-feron alpha and ribavirin. After long-term follow-up, de novo T2DM incidence significantly decreased, and triglyceride levels significantly increased in treatment responders. Only steatosis tended to affect treatment response. The association between HCV and lipid metabolic pathways may be important even with new direct antiviral agents. Patients infected with HCV should be screened for T2DM.
Publish Date	2016-10-25 08:46
Citation	Yair-Sabag S, Nussinson E, Ben-Assuli O, Shibli F, Shahbari A, Zelber-Sagi S. Retrospective study of the associations between hepatitis C virus infection and metabolic factors. World J Hepatol 2016; 8(30): 1269-1278
URL	http://www.wjgnet.com/1948-5182/full/v8/i30/1269.htm
DOI	http://dx.doi.org/10.4254/wjh.v8.i30.1269

Full Article (PDF)	WJH-8-1269.pdf
Full Article (Word)	WJH-8-1269.doc