| ISSN |
1007-9327 (print) and 2219-2840 (online) |
| Open Access |
This article is an open-access article which was
selected by an in-house editor and fully peer-reviewed by external
reviewers. It is distributed in accordance with the Creative
Commons Attribution Non Commercial (CC BY-NC 4.0) license,
which permits others to distribute, remix, adapt, build upon this
work non-commercially, and license their derivative works on
different terms, provided the original work is properly cited and
the use is non-commercial. See: http://creativecommons.org/
licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2016. Published by Baishideng Publishing
Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Gastroenterology & Hepatology |
| Manuscript Type |
Observational Study |
| Article Title |
Detection of Helicobacter pylori resistance to clarithromycin and fluoroquinolones in Brazil: A national survey
|
| Manuscript Source |
Invited Manuscript |
| All Author List |
Bruno Squarcio Sanches, Gustavo Miranda Martins, Karine Lima, Bianca Cota, Luciana Dias Moretzsohn, Laercio Tenorio Ribeiro, Helenice P Breyer, Ismael Maguilnik, Aline Bessa Maia, Joffre Rezende-Filho, Ana Carolina Meira, Henrique Pinto, Edson Alves, Ramiro Mascarenhas, Raissa Passos, Julia Duarte de Souza, Osmar Reni Trindade and Luiz Gonzaga Coelho |
| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| Fundação de Amparo à Pesquisa do Estado de Minas Gerais (FAPEMIG) |
|
| Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq) |
|
|
| Corresponding Author |
Luiz Gonzaga Coelho, PhD, Professor of Medicine, Department of Internal Medicine, Head of Alfa Institute of Gastroenterology, School of Medicine, Federal University of Minas Gerais, Belo Horizonte 30130-100, Minas Gerais, Brazil. lcoelho22@gmail.com |
| Key Words |
Helicobacter pylori; Microbial drug resistance; Clarithromycin; Fluoroquinolones; Molecular diagnostic techniques |
| Core Tip |
Antibiotic resistance is the main cause of failure in the treatment of Helicobacter pylori (H. pylori) infection. Using molecular methods, this study investigated bacterial resistance to clarithromycin and fluoroquinolones in 490 adult patients recruited from five regions in Brazil. These patients had never been previously treated for H. pylori infection. Clarithromycin and fluoroquinolone resistance was found in 16.9% and 13.5% of patients, respectively. Resistance to both drugs was found in 4.3% of patients. The mean primary H. pylori clarithromycin resistance rate in Brazil is at the borderline for applying the standard triple therapy, and the primary fluoroquinolone resistance rate is concerning. |
| Publish Date |
2016-09-04 14:49 |
| Citation |
Sanches BS, Martins GM, Lima K, Cota B, Moretzsohn LD, Ribeiro LT, Breyer HP, Maguilnik I, Maia AB, Rezende-Filho J, Meira AC, Pinto H, Alves E, Mascarenhas R, Passos R, de Souza JD, Trindade OR, Coelho LG. Detection of Helicobacter pylori resistance to clarithromycin and fluoroquinolones in Brazil: a national survey. World J Gastroenterol 2016; 22(33): 7587-7594 |
| URL |
http://www.wjgnet.com/1007-9327/full/v22/i33/7587.htm |
| DOI |
http://dx.doi.org/10.3748/wjg.v22.i33.7587 |
