Publication Name	World Journal of Psychiatry
Manuscript ID	27320
Country	Israel

Received	2016-05-24 09:20
Peer-Review Started	2016-05-25 09:22
To Make the First Decision	2016-07-04 15:43
Return for Revision	2016-07-06 08:32
Revised	2016-07-21 19:16
Second Decision	2016-07-28 14:52
Accepted by Journal Editor-in-Chief	2016-07-29 06:37
Accepted by Executive Editor-in-Chief	2016-08-08 14:38
Articles in Press	2016-08-08 14:38
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2016-09-13 13:18
Publish the Manuscript Online	2016-09-19 14:59

ISSN	2220-3206 (online)
Open Access	This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright	© The Author(s) 2016. Published by Baishideng Publishing Group Inc. All rights reserved.
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Category	Behavioral Sciences
Manuscript Type	Review
Article Title	Gene environment interaction in periphery and brain converge to modulate behavioral outcomes: Insights from the SP1 transient early in life interference rat model
Manuscript Source	Invited Manuscript
All Author List	Eyal Asor and Dorit Ben-Shachar
Funding Agency and Grant Number
Corresponding Author	Dorit Ben-Shachar, Professor, Laboratory of Psychobiology, Department of Psychiatry, Rambam Medical Center and B. Rappaport Faculty of Medicine, Rappaport Family Institute for Research in the Medical Sciences, Technion, PO Box 9649, Haifa 31096, Israel. shachar@tx.technion.ac.il
Key Words	Gene-environmental interaction; Specificity protein 1; Mithramycin; Stress; Animal-model; Essential amino acids; Tryptophan; Insulin
Core Tip	We review the main theoretical and practical concepts in the research of gene environment interaction. We present a novel approach to study gene environment interaction in which a brief post-natal interference with the expression of multiple genes by inhibiting the activity of the ubiquitous transcription factor specificity protein 1 is followed by later-in-life exposure of rats to stress. Finally, we discuss the role of peripheral processes in behavioral responses, demonstrating how specific behavioral patterns are linked to modulations in interwoven brain and body physiological processes due to gene and environmental changes.
Publish Date	2016-09-19 14:59
Citation	Asor E, Ben-Shachar D. Gene environment interaction in periphery and brain converge to modulate behavioral outcomes: Insights from the SP1 transient early in life interference rat model. World J Psychiatr 2016; 6(3): 294-302
URL	http://www.wjgnet.com/2220-3206/full/v6/i3/294.htm
DOI	http://dx.doi.org/10.5498/wjp.v6.i3.294

Full Article (PDF)	WJP-6-294.pdf
Full Article (Word)	WJP-6-294.doc
Manuscript File	27320-Review.docx
Answering Reviewers	27320-Answering reviewers.pdf
Audio Core Tip	27320-Audio core tip.mp3
Conflict-of-Interest Disclosure Form	27320-Conflict-of-interest statement.pdf
Copyright License Agreement	27320-Copyright assignment.pdf
Peer-review Report	27320-Peer-review(s).pdf
Journal Editor-in-Chief Review Report	27320-Journal editor-in-chief review report.pdf
Scientific Misconduct Check	27320-Scientific misconduct check.pdf
Scientific Editor Work List	27320-Scientific editor work list.pdf