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10/20/2016 5:06:00 PM | Browse: 725 | Download: 444
Publication Name World Journal of Gastroenterology
Manuscript ID 27355
Country/Territory Israel
2016-05-26 09:05
Peer-Review Started
2016-05-27 15:32
To Make the First Decision
2016-07-13 13:30
Return for Revision
2016-07-18 09:25
2016-07-21 15:35
Second Decision
2016-07-30 14:52
Accepted by Journal Editor-in-Chief
2016-08-01 23:33
Accepted by Company Editor-in-Chief
2016-08-05 17:54
Articles in Press
2016-08-05 17:54
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript
2016-10-13 12:36
Publish the Manuscript Online
2016-10-20 17:06
ISSN 1007-9327 (print) and 2219-2840 (online)
Open Access This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright © The Author(s) 2016. Published by Baishideng Publishing Group Inc. All rights reserved.
Article Reprints For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
Permissions For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website http://www.wjgnet.com
Category Gastroenterology and Hepatology
Manuscript Type Basic Study
Article Title Oral administration of a non-absorbable plant cell-expressed recombinant anti-TNF fusion protein induces immunomodulatory effects and alleviates nonalcoholic steatohepatitis
Manuscript Source Unsolicited Manuscript
All Author List Yaron Ilan, Ami Ben Ya'acov, Yehudit Shabbat, Svetlana Gingis-Velitski, Einat Almon and Yoseph Shaaltiel
Funding Agency and Grant Number
Funding Agency Grant Number
Protalix Biotherapeutics and The Roman-Epstein Liver Research Foundation in part
Corresponding author Yaron Ilan, MD, Gastroenterology and Liver Units, Department of Medicine, Hadassah Hebrew University Medical Center, Ein-Karem, POB 1200, Jerusalem IL91120, Israel. ilan@hadassah.org.il
Keywords Nonalcoholic steatohepatitis; Nonalcoholic fatty liver disease; Tumor necrosis alpha; Enbrel; Diabetes
Core Tip The BY-2 plant cell-expressed recombinant anti-tumor necrosis factor alpha (TNF) fusion protein (PRX-106) that consists of the soluble form of the human TNF receptor fused to the Fc component of a human IgG1 domain was orally administered in high-fat diet model. Altered distribution of CD4+CD25+FoxP3+ and a decrease in the intrasplenic-to-intrahepatic CD8+CD25+FoxP3+ ratio were observed. These effects were associated with a decrease in serum triglyceride levels, decrease in the aspartate aminotransferase levels, serum glucose levels, and HOMA-IR score. A decrease in hepatic triglycerides content was observed in the high dose-treated mice. The data suggest that PRX-106 may provide an oral immunotherapy for nonalcoholic steatohepatitis.
Publish Date 2016-10-20 17:06
Citation Ilan Y, Ben Ya'acov A, Shabbat Y, Gingis-Velitski S, Almon E, Shaaltiel Y. Oral administration of a non-absorbable plant cell-expressed recombinant anti-TNF fusion protein induces immunomodulatory effects and alleviates nonalcoholic steatohepatitis. World J Gastroenterol 2016; 22(39): 8760-8769
Url http://www.wjgnet.com/1007-9327/full/v22/i39/8760.htm
DOI http://dx.doi.org/10.3748/wjg.v22.i39.8760
Full Article (PDF) WJG-22-8760.pdf
Full Article (Word) WJG-22-8760.doc
Manuscript File 27355-Review.docx
Answering Reviewers 27355-Answering reviewers.pdf
Audio Core Tip 27355-Audio core tip.m4a
Biostatistics Review Certificate Biostatistics_Statement_20160525214938.docx
Conflict-of-Interest Disclosure Form 27355-Conflict-of-interest statement.pdf
Copyright License Agreement 27355-Copyright assignment.pdf
Institutional Animal Care and Use Committee Approval Form or Document Institutional_Animal_Care_and_Use_Committee_Statement_20160525214737.docx
Peer-review Report 27355-Peer-review(s).pdf
Journal Editor-in-Chief Review Report 27355-Journal editor-in-chief review report.pdf
Scientific Misconduct Check 27355-Scientific misconduct check.pdf
Scientific Editor Work List 27355-Scientific editor work list.pdf