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Articles Published Processes
10/20/2016 5:06:00 PM | Browse: 1394 | Download: 1575
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Received |
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2016-05-26 09:05 |
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Peer-Review Started |
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2016-05-27 15:32 |
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To Make the First Decision |
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2016-07-13 13:30 |
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Return for Revision |
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2016-07-18 09:25 |
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Revised |
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2016-07-21 15:35 |
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Second Decision |
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2016-07-30 14:52 |
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Accepted by Journal Editor-in-Chief |
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2016-08-01 23:33 |
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Accepted by Executive Editor-in-Chief |
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2016-08-05 17:54 |
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Articles in Press |
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2016-08-05 17:54 |
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Publication Fee Transferred |
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Edit the Manuscript by Language Editor |
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Typeset the Manuscript |
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2016-10-13 12:36 |
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Publish the Manuscript Online |
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2016-10-20 17:06 |
| ISSN |
1007-9327 (print) and 2219-2840 (online) |
| Open Access |
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2016. Published by Baishideng Publishing Group Inc. All rights reserved.
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| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Gastroenterology & Hepatology |
| Manuscript Type |
Basic Study |
| Article Title |
Oral administration of a non-absorbable plant cell-expressed recombinant anti-TNF fusion protein induces immunomodulatory effects and alleviates nonalcoholic steatohepatitis
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| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Yaron Ilan, Ami Ben Ya'acov, Yehudit Shabbat, Svetlana Gingis-Velitski, Einat Almon and Yoseph Shaaltiel |
| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| Protalix Biotherapeutics and The Roman-Epstein Liver Research Foundation |
in part |
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| Corresponding Author |
Yaron Ilan, MD, Gastroenterology and Liver Units, Department of Medicine, Hadassah Hebrew University Medical Center, Ein-Karem, POB 1200, Jerusalem IL91120, Israel. ilan@hadassah.org.il
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| Key Words |
Nonalcoholic steatohepatitis; Nonalcoholic fatty liver disease; Tumor necrosis alpha; Enbrel; Diabetes |
| Core Tip |
The BY-2 plant cell-expressed recombinant anti-tumor necrosis factor alpha (TNF) fusion protein (PRX-106) that consists of the soluble form of the human TNF receptor fused to the Fc component of a human IgG1 domain was orally administered in high-fat diet model. Altered distribution of CD4+CD25+FoxP3+ and a decrease in the intrasplenic-to-intrahepatic CD8+CD25+FoxP3+ ratio were observed. These effects were associated with a decrease in serum triglyceride levels, decrease in the aspartate aminotransferase levels, serum glucose levels, and HOMA-IR score. A decrease in hepatic triglycerides content was observed in the high dose-treated mice. The data suggest that PRX-106 may provide an oral immunotherapy for nonalcoholic steatohepatitis.
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| Publish Date |
2016-10-20 17:06 |
| Citation |
Ilan Y, Ben Ya'acov A, Shabbat Y, Gingis-Velitski S, Almon E, Shaaltiel Y. Oral administration of a non-absorbable plant cell-expressed recombinant anti-TNF fusion protein induces immunomodulatory effects and alleviates nonalcoholic steatohepatitis. World J Gastroenterol 2016; 22(39): 8760-8769 |
| URL |
http://www.wjgnet.com/1007-9327/full/v22/i39/8760.htm |
| DOI |
http://dx.doi.org/10.3748/wjg.v22.i39.8760 |
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