Publication Name	World Journal of Hematology
Manuscript ID	2744
Country	Japan

Received	2013-03-12 08:45
Peer-Review Started	2013-03-12 15:53
To Make the First Decision	2013-04-16 09:22
Return for Revision	2013-04-20 20:03
Revised	2013-05-10 16:40
Second Decision	2013-06-06 09:22
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2013-06-06 13:02
Articles in Press
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2013-07-15 15:41
Publish the Manuscript Online	2013-07-25 22:33

ISSN	2218-6204 (online)
Open Access
Copyright
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Website	http://www.wjgnet.com

Category	Hematology
Manuscript Type	Case Report
Article Title	Management of adult Langerhans cell histiocytosis based on the characteristic clinical features
Manuscript Source	Invited Manuscript
All Author List	Shinsaku Imashuku, Chihiro Shimazaki, Arinobu Tojo, Toshihiko Imamura and Akira Morimoto
Funding Agency and Grant Number
Corresponding Author	Shinsaku Imashuku, MD, Consultant, Division of Hematology, Takasago-seibu Hospital, 1-10-41 Nakasuji, Takasago 676-0812, Japan. shinim95@mbox.kyoto-inet.or.jp
Key Words	Langerhans cell histiocytosis; Adult; Immuno-chemotherapy; 2-chlorodeoxyadenosine; Childbirth
Core Tip	Clinical features and treatment in a total of 18 adult patients with langerhans cell histiocytosis (LCH) were reviewed. We found two major groups regarding the initial symptoms; one was central diabetes insipidus and other endocrine symptoms (n = 9) and the other bone diseases (n = 8; 1 skull, 4 spinal and 3 multiple). We also recognized the correlation between pregnancy/childbirth and LCH in 4 patients. Based on the clinical features and outcomes, early diagnosis and rapid introduction of appropriate treatment are essential, in order to overcome the problems relevant to adult LCH.
Publish Date	2013-07-25 22:33
Citation	Imashuku S, Shimazaki C, Tojo A, Imamura T, Morimoto A. Management of adult Langerhans cell histiocytosis based on the characteristic clinical features. World J Hematol 2013; 2(3): 89-98
URL	http://www.wjgnet.com/2218-6204/full/v2/i3/89.htm
DOI	http://dx.doi.org/10.5315/wjh.v2.i3.89

Full Article (PDF)	WJH-2-89.pdf
Manuscript File	2744-Review.doc
Answering Reviewers	2744-Answering reviewers.docx
Copyright License Agreement	2744-Copyright assignment.pdf
Non-Native Speakers of English Editing Certificate	2744-Language certificate.pdf
Peer-review Report	2744-Peer review(s).pdf
Scientific Editor Work List	2744-Scientific editor work list.doc