BPG is committed to discovery and dissemination of knowledge
Articles Published Processes
4/13/2017 3:45:15 PM | Browse: 1182 | Download: 1926
Publication Name World Journal of Hepatology
Manuscript ID 27502
Country/Territory United States
Received
2016-06-03 08:44
Peer-Review Started
To Make the First Decision
Return for Revision
Revised
Second Decision
2017-03-07 15:24
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief
2017-03-17 13:58
Articles in Press
2017-03-17 13:58
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript
2017-03-31 14:17
Publish the Manuscript Online
2017-04-13 15:45
ISSN 1948-5182 (online)
Open Access This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright © The Author(s) 2017. Published by Baishideng Publishing Group Inc. All rights reserved.
Article Reprints For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
Permissions For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website http://www.wjgnet.com
Category Gastroenterology & Hepatology
Manuscript Type Observational Study
Article Title Factors associated with success of telaprevir- and boceprevir-based triple therapy for hepatitis C virus infection
Manuscript Source Invited Manuscript
All Author List Kian Bichoupan, Neeta Tandon, Valerie Martel-Laferriere, Neal M Patel, David Sachs, Michel Ng, Emily A Schonfeld, Alexis Pappas, James Crismale, Alicia Stivala, Viktoriya Khaitova, Donald Gardenier, Michael Linderman, William Olson, Ponni V Perumalswami, Thomas D Schiano, Joseph A Odin, Lawrence U Liu, Douglas T Dieterich and Andrea D Branch
Funding Agency and Grant Number
Funding Agency Grant Number
JANSSEN SCIENTIFIC AFFAIRS, LLC To Andrea D Branch
Corresponding Author Dr. Kian Bichoupan, Division of Liver Diseases, Icahn School of Medicine at Mount Sinai, Icahn Medical Instititute, 11th floor, Room 34, 1425 Madison Avenue, New York, NY 10029, United States. kian.bichoupan@mssm.edu
Key Words Sustained virologic response; Hepatitis C virus; Relapse; Telaprevir; Boceprevir; Triple-therapy; Classification and regression; Adverse event; Real-world
Core Tip A cohort of 223 hepatitis C virus (HCV)-infected patients at a tertiary referral center was analyzed. All patients were treated with telaprevir and boceprevir. Using both logistic regression and a machine learning techniques we identified baseline and on-treatment factors associated with sustained virologic response and relapse. We found that both low platelet count and advanced fibrosis or cirrhosis were associated with treatment failure. Information of the effectiveness of these protease inhibitors could be used to inform clinical trials of future HCV direct-acting antivirals.
Publish Date 2017-04-13 15:45
Citation Bichoupan K, Tandon N, Martel-Laferriere V, Patel NM, Sachs D, Ng M, Schonfeld EA, Pappas A, Crismale J, Stivala A, Khaitova V, Gardenier D, Linderman M, Olson W, Perumalswami PV, Schiano TD, Odin JA, Liu LU, Dieterich DT, Branch AD. Factors associated with success of telaprevir- and boceprevir-based triple therapy for hepatitis C virus infection. World J Hepatol 2017; 9(11): 551-561
URL http://www.wjgnet.com/1948-5182/full/v9/i11/551.htm
DOI http://dx.doi.org/10.4254/wjh.v9.i11.551
Full Article (PDF) WJH-9-551.pdf
Full Article (Word) WJH-9-551.doc
Manuscript File 27502-Review.docx
Answering Reviewers 27502-Answering reviewers.pdf
Audio Core Tip 27502-Audio core tip.mp3
Conflict-of-Interest Disclosure Form 27502-Conflict-of-interest statement.pdf
Copyright License Agreement 27502-Copyright assignment.pdf
Approved Grant Application Form(s) or Funding Agency Copy of any Approval Document(s) 27502-Grant application form(s).pdf
Signed Informed Consent Form(s) or Document(s) Informed_Consent_Statement_20160601125431.pdf
Institutional Review Board Approval Form or Document 27502-Institutional review board statement.pdf
Supplementary Material 27502-Supplementary material.pdf
Peer-review Report 27502-Peer-review(s).pdf
Scientific Misconduct Check 27502-Scientific misconduct check.pdf
Scientific Editor Work List 27502-Scientific editor work list.pdf