Publication Name	World Journal of Gastroenterology
Manuscript ID	27532
Country	Netherlands

Received	2016-06-03 09:56
Peer-Review Started	2016-06-03 16:32
To Make the First Decision	2016-07-12 09:23
Return for Revision	2016-07-15 15:29
Revised	2016-07-20 19:32
Second Decision	2016-08-05 10:18
Accepted by Journal Editor-in-Chief	2016-08-05 14:24
Accepted by Executive Editor-in-Chief	2016-08-10 15:48
Articles in Press	2016-08-10 15:48
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2016-10-18 21:51
Publish the Manuscript Online	2016-10-26 17:34

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access	This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright	© The Author(s) 2016. Published by Baishideng Publishing Group Inc. All rights reserved.
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Category	Gastroenterology & Hepatology
Manuscript Type	Systematic Reviews
Article Title	Efficacy of thioguanine treatment in inflammatory bowel disease: A systematic review
Manuscript Source	Unsolicited Manuscript
All Author List	Berrie Meijer, Chris JJ Mulder, Godefridus J Peters, Adriaan A van Bodegraven and Nanne KH de Boer
Funding Agency and Grant Number
Corresponding Author	Berrie Meijer, MD, Department of Gastroenterology and Hepatology, VU University Medical Center, De Boelelaan 1118, 1081 HV Amsterdam, The Netherlands. b.meijer1@vumc.nl
Key Words	Thiopurines; Thioguanine; Inflammatory bowel disease; Crohn’s disease; Ulcerative colitis
Core Tip	Whereas conventional thiopurines are globally accepted as second-line treatment of inflammatory bowel disease (IBD) patients, almost half of these patients discontinues this treatment due to ineffectiveness or intolerance. In this systematic review, the efficacy of thioguanine treatment, a thiopurine with a less extensive and complex metabolism, is systematically assessed to determine if this drug is an alternative in the treatment of IBD patients intolerant or ineffective to azathioprine and/or mercaptopurine. We showed that up to 65% of patients benefit of a switch to thioguanine, thus preserving these patients from potentially more harmful and expensive treatment with biologicals.
Publish Date	2016-10-26 17:34
Citation	Meijer B, Mulder CJJ, Peters GJ, van Bodegraven AA, de Boer NKH. Efficacy of thioguanine treatment in inflammatory bowel disease: A systematic review. World J Gastroenterol 2016; 22(40): 9012-9021
URL	http://www.wjgnet.com/1007-9327/full/v22/i40/9012.htm
DOI	http://dx.doi.org/10.3748/wjg.v22.i40.9012

Full Article (PDF)	WJG-22-9012.pdf
Full Article (Word)	WJG-22-9012.doc
Manuscript File	27532-Review.docx
Answering Reviewers	27532-Answering reviewers.pdf
Audio Core Tip	27532-Audio core tip.mp3
Conflict-of-Interest Disclosure Form	27532-Conflict-of-interest statement.pdf
Copyright License Agreement	27532-Copyright assignment.pdf
Supplementary Material	Supplementary_Material_20160602171941.pdf
Peer-review Report	27532-Peer-review(s).pdf
Journal Editor-in-Chief Review Report	27532-Journal editor-in-chief review report.pdf
Scientific Misconduct Check	27532-Scientific misconduct check.pdf
Scientific Editor Work List	27532-Scientific editor work list.pdf