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10/20/2016 5:06:00 PM | Browse: 1089 | Download: 2316
Publication Name World Journal of Gastroenterology
Manuscript ID 27739
Country/Territory China
Received
2016-06-15 14:09
Peer-Review Started
2016-06-16 15:22
To Make the First Decision
2016-07-29 16:27
Return for Revision
2016-08-02 11:00
Revised
2016-08-15 17:31
Second Decision
2016-08-24 12:07
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief
2016-08-30 16:42
Articles in Press
2016-08-30 16:42
Publication Fee Transferred
Edit the Manuscript by Language Editor
2016-09-09 16:33
Typeset the Manuscript
2016-10-13 16:51
Publish the Manuscript Online
2016-10-20 17:06
ISSN 1007-9327 (print) and 2219-2840 (online)
Open Access This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright © The Author(s) 2016. Published by Baishideng Publishing Group Inc. All rights reserved.
Article Reprints For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
Permissions For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website http://www.wjgnet.com
Category Oncology
Manuscript Type Retrospective Study
Article Title Cyclooxygenase-2 expression is associated with initiation of hepatocellular carcinoma, while prostaglandin receptor-1 expression predicts survival
Manuscript Source Unsolicited Manuscript
All Author List Hao-Jie Yang, Jing-Hang Jiang, Yu-Ting Yang, Xiang-Di Yang, Zhe Guo, Ya-Peng Qi, Feng-Hua Zeng, Ke-Lan Zhang, Neng-Zhi Chen, Bang-De Xiang and Le-Qun Li
Funding Agency and Grant Number
Funding Agency Grant Number
National Natural Science Foundation of China 81260331
Key Laboratory for High-Incidence Tumor Prevention and Treatment, Ministry of Education GKE2015-ZZ05
Corresponding Author Dr. Bang-De Xiang, Professor, Department of Hepatobiliary Surgery, Affiliated Tumor Hospital of Guangxi Medical University, 71 Hedi Road, Nanning 530021, Guangxi Zhuang Autonomous Region, China. yhj894924067@163.com
Key Words Cyclooxygenase-2; Hepatocellular carcinoma; Liver resection; Prognosis; Prostaglandin E1 receptor
Core Tip We retrospectively reviewed the records of 116 patients with hepatocellular carcinoma (HCC) who underwent surgery between 2008 and 2011 at our hospital. Our results suggest that the factors associated with poor overall survival were alpha-fetoprotein > 400 ng/mL, tumor size ≥ 5 cm, and high prostaglandin E1 (EP1) receptor expression, but not high cyclooxygenase-2 (COX-2) expression. Disease-free survival did not differ significantly between patients with low or high levels of COX-2 or EP1. COX-2 immunoreactivity was significantly higher in well-differentiated HCC tissues (Edmondson grade?Ⅰ-Ⅱ) than in poorly differentiated tissues (Edmondson grade Ⅲ-Ⅳ) (p = 0.003). EP1 receptor immunoreactivity was significantly higher in poorly differentiated tissue than in well-differentiated tissue (p = 0.001).
Publish Date 2016-10-20 17:06
Citation Yang HJ, Jiang JH, Yang YT, Yang XD, Guo Z, Qi YP, Zeng FH, Zhang KL, Chen NZ, Xiang BD, Li LQ. Cyclooxygenase-2 expression is associated with initiation of hepatocellular carcinoma, while prostaglandin receptor-1 expression predicts survival. World J Gastroenterol 2016; 22(39): 8798-8805
URL http://www.wjgnet.com/1007-9327/full/v22/i39/8798.htm
DOI http://dx.doi.org/10.3748/wjg.v22.i39.8798
Full Article (PDF) WJG-22-8798.pdf
Full Article (Word) WJG-22-8798.doc
Manuscript File 27739-Review.docx
Answering Reviewers 27739-Answering reviewers.pdf
Audio Core Tip 27739-Audio core tip.mp3
Biostatistics Review Certificate 27739-Biostatistics statement.pdf
Clinical Trial Registration Statement DeclarationOf_HelsinkiConformation_Statement_20160614145447.docx
Conflict-of-Interest Disclosure Form 27739-Conflict-of-interest statement.pdf
Copyright License Agreement 27739-Copyright assignment.pdf
Approved Grant Application Form(s) or Funding Agency Copy of any Approval Document(s) 27739-Grant application form(s).pdf
Signed Informed Consent Form(s) or Document(s) Informed_Consent_Statement_20160614145445.docx
Institutional Animal Care and Use Committee Approval Form or Document Institutional_Animal_Care_and_Use_Committee_Statement_20160614150432.docx
Institutional Review Board Approval Form or Document 27739-Institutional review board statement.pdf
Non-Native Speakers of English Editing Certificate 27739-Language certificate.pdf
Video Video_20160614150345.docx
Supplementary Material Supplementary_Material_20160614150339.docx
Peer-review Report 27739-Peer-review(s).pdf
Scientific Misconduct Check 27739-Scientific misconduct check.pdf
Scientific Editor Work List 27739-Scientific editor work list.pdf