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Articles Published Processes
10/26/2016 5:33:00 PM | Browse: 905 | Download: 1645
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Received |
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2016-06-21 10:46 |
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Peer-Review Started |
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2016-06-21 12:02 |
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To Make the First Decision |
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2016-08-08 08:51 |
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Return for Revision |
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2016-08-09 16:21 |
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Revised |
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Second Decision |
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2016-09-21 15:01 |
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Accepted by Journal Editor-in-Chief |
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2016-09-24 00:14 |
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Accepted by Company Editor-in-Chief |
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2016-09-28 18:53 |
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Articles in Press |
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2016-09-28 18:53 |
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Publication Fee Transferred |
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Edit the Manuscript by Language Editor |
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Typeset the Manuscript |
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2016-10-16 10:35 |
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Publish the Manuscript Online |
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2016-10-26 17:34 |
| ISSN |
1007-9327 (print) and 2219-2840 (online) |
| Open Access |
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2016. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Gastroenterology & Hepatology |
| Manuscript Type |
Basic Study |
| Article Title |
Polymorphisms and resistance mutations of hepatitis C virus on sequences in the European hepatitis C virus database
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| Manuscript Source |
Invited Manuscript |
| All Author List |
Dimas Alexandre Kliemann, Cristiane Valle Tovo, Ana Beatriz Gorini da Veiga, Angelo Alves de Mattos and Charles Wood |
| Funding Agency and Grant Number |
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| Corresponding Author |
Dimas Alexandre Kliemann, MD, PhD, Hospital Nossa Senhora da Conceição - Serviço de Infectologia, Av. Francisco Trein, 596, bairro Cristo Redentor, Porto Alegre, Rio Grande do Sul 91350-170, Brazil. dimaskliemann@gmail.com |
| Key Words |
Hepatitis C virus resistance; Quasispecies; Direct antiviral agents; Polymorphisms; Drug resistance |
| Core Tip |
Chronic hepatitis C virus (HCV) infection is a significant cause morbidity and mortality. The main therapeutic targets are the NS3/4A protease, NS5B polymerase, and NS5A replication complex. Pre-existence of resistance associated variants to direct antiviral agents (DAA) reduces sustained virologic response rates. Despite the low frequency of mutations, this resistant population is likely to be selected in patients undergoing therapy with DAA. Even though HCV variants resistant to DAA targeting one viral protein remain susceptible to DAA targeting another viral protein, combination therapy could fail due to selection of HCV with resistance substitutions in multiple targets. |
| Publish Date |
2016-10-26 17:34 |
| Citation |
Kliemann DA, Tovo CV, da Veiga ABG, de Mattos AA, Wood C. Polymorphisms and resistance mutations of hepatitis C virus on sequences in the European hepatitis C virus database. World J Gastroenterol 2016; 22(40): 8910-8917 |
| URL |
http://www.wjgnet.com/1007-9327/full/v22/i40/8910.htm |
| DOI |
http://dx.doi.org/10.3748/wjg.v22.i40.8910 |
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