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11/16/2016 10:47:00 AM | Browse: 378 | Download: 451
Publication Name World Journal of Hepatology
Manuscript ID 28077
Country of Manuscript Source Egypt
Received
2016-06-27 14:19
Peer-Review Started
2016-06-28 09:58
To Make the First Decision
2016-09-01 17:00
Return for Revision
2016-09-02 09:03
Revised
2016-09-09 07:38
Second Decision
2016-09-20 15:50
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief
2016-10-09 10:32
Articles in Press
2016-10-09 10:32
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript
2016-11-13 13:17
Publish the Manuscript Online
2016-11-16 10:47
ISSN 1948-5182 (online)
Open Access This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright © The Author(s) 2016. Published by Baishideng Publishing Group Inc. All rights reserved.
Article Reprints For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
Permissions For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website http://www.wjgnet.com
Category Gastroenterology and Hepatology
Manuscript Type Observational Study
Article Title Novel non-invasive biological predictive index for liver fibrosis in hepatitis C virus genotype 4 patients
Manuscript Source Invited Manuscript
All Author List Mahmoud Khattab, Mohamed Amin Sakr, Mohamed Abdel Fattah, Youssef Mousa, Elwy Soliman, Ashraf Breedy, Mona Fathi, Salwa Gaber, Ahmed Altaweil, Ashraf Osman, Ahmed Hassouna and Ibrahim Motawea
Funding Agency and Grant Number
Funding Agency Grant Number
Governmental Foundation Scientific and Technology Development Foundation 1538
Corresponding author Mahmoud Khattab, MD, PhD, Professor of Medicine, Head of Liver Unit, Department of Internal Medicine, Minia University, Cornish Al Nile Road, Minia 61111, Egypt. mkhattabmed@hotmail.com
Keywords Liver fibrosis; Insulin resistance; Aspartate amino transaminase; Platelets; Age
Core Tip This observational study included a cohort of 332 recruited patients with hepatitis C virus (HCV) genotype 4 infections. The study assessed the status of demographic and biological variables at different stages of liver fibrosis. Liver biopsy with Metavir scoring was the reference standard used to classify patients into five stages of liver fibrosis (F0-F4). Patient regrouping to include three levels of fibrosis, mild (F0-F1), moderate (F2), and advanced (F3-F4), was performed to conform with practical guidelines for the management and follow-up of HCV patients. Age, aspartate transaminase enzyme (AST), insulin resistance (HOMA-IR), and platelet count were significant predictors of liver fibrosis as shown on univariate analysis. Log AST, log HOMA-IR, log platelet count and age were introduced into stepwise multivariate discriminative analysis, and a model for the prediction of liver fibrosis level was derived. Our pre-dictive index exhibited an area under the curve (AUC) of 0.91 for the diagnosis of advanced stages of fibrosis and an AUC of 0.88 for the diagnosis of mild stages of fibrosis. The index exhibited a lower AUC of 0.64 in the diagnosis of moderate stages of fibrosis.
Publish Date 2016-11-16 10:47
Citation Khattab M, Sakr MA, Fattah MA, Mousa Y, Soliman E, Breedy A, Fathi M, Gaber S, Altaweil A, Osman A, Hassouna A, Motawea I. Novel non-invasive biological predictive index for liver fibrosis in hepatitis C virus genotype 4 patients. World J Hepatol 2016; 8(32): 1392-1401
Url http://www.wjgnet.com/1948-5182/full/v8/i32/1392.htm
DOI http://dx.doi.org/10.4254/wjh.v8.i32.1392
Full Article (PDF) WJH-8-1392.pdf
Full Article (Word) WJH-8-1392.doc
Manuscript File 28077-Review.docx
Answering Reviewers 28077-Answering reviewers.pdf
Audio Core Tip 28077-Audio core tip.mp3
Biostatistics Review Certificate 28077-Biostatistics statement.pdf
Conflict-of-Interest Disclosure Form 28077-Conflict-of-interest statement.pdf
Copyright License Agreement 28077-Copyright assignment.pdf
Approved Grant Application Form(s) or Funding Agency Copy of any Approval Document(s) 28077-Grant application form(s).pdf
Signed Informed Consent Form(s) or Document(s) Informed_Consent_Statement_20160626062126.pdf
Institutional Review Board Approval Form or Document 28077-Institutional review board statement.pdf
Non-Native Speakers of English Editing Certificate 28077-Language certificate.pdf
Peer-review Report 28077-Peer-review(s).pdf
Scientific Misconduct Check 28077-Scientific misconduct check.pdf
Scientific Editor Work List 28077-Scientific editor work list.pdf