Publication Name	World Journal of Hepatology
Manuscript ID	28077
Country	Egypt

Received	2016-06-27 14:19
Peer-Review Started	2016-06-28 09:58
First Decision by Editorial Office Director
Return for Revision	2016-09-02 09:03
Revised	2016-09-09 07:38
Publication Fee Transferred
Second Decision by Editor	2016-09-20 15:50
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director	2016-10-09 10:32
Articles in Press	2016-10-09 10:32
Edit the Manuscript by Language Editor
Typeset the Manuscript	2016-11-13 13:17
Publish the Manuscript Online	2016-11-16 10:47

ISSN	1948-5182 (online)
Open Access	This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright	© The Author(s) 2016. Published by Baishideng Publishing Group Inc. All rights reserved.
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Category	Gastroenterology & Hepatology
Manuscript Type	Observational Study
Article Title	Novel non-invasive biological predictive index for liver fibrosis in hepatitis C virus genotype 4 patients
Manuscript Source	Invited Manuscript
All Author List	Mahmoud Khattab, Mohamed Amin Sakr, Mohamed Abdel Fattah, Youssef Mousa, Elwy Soliman, Ashraf Breedy, Mona Fathi, Salwa Gaber, Ahmed Altaweil, Ashraf Osman, Ahmed Hassouna and Ibrahim Motawea
Funding Agency and Grant Number	Funding Agency Grant Number Governmental Foundation Scientific and Technology Development Foundation 1538
Corresponding Author	Mahmoud Khattab, MD, PhD, Professor of Medicine, Head of Liver Unit, Department of Internal Medicine, Minia University, Cornish Al Nile Road, Minia 61111, Egypt. mkhattabmed@hotmail.com
Key Words	Liver fibrosis; Insulin resistance; Aspartate amino transaminase; Platelets; Age
Core Tip	This observational study included a cohort of 332 recruited patients with hepatitis C virus (HCV) genotype 4 infections. The study assessed the status of demographic and biological variables at different stages of liver fibrosis. Liver biopsy with Metavir scoring was the reference standard used to classify patients into five stages of liver fibrosis (F0-F4). Patient regrouping to include three levels of fibrosis, mild (F0-F1), moderate (F2), and advanced (F3-F4), was performed to conform with practical guidelines for the management and follow-up of HCV patients. Age, aspartate transaminase enzyme (AST), insulin resistance (HOMA-IR), and platelet count were significant predictors of liver fibrosis as shown on univariate analysis. Log AST, log HOMA-IR, log platelet count and age were introduced into stepwise multivariate discriminative analysis, and a model for the prediction of liver fibrosis level was derived. Our pre-dictive index exhibited an area under the curve (AUC) of 0.91 for the diagnosis of advanced stages of fibrosis and an AUC of 0.88 for the diagnosis of mild stages of fibrosis. The index exhibited a lower AUC of 0.64 in the diagnosis of moderate stages of fibrosis.
Publish Date	2016-11-16 10:47
Citation	Khattab M, Sakr MA, Fattah MA, Mousa Y, Soliman E, Breedy A, Fathi M, Gaber S, Altaweil A, Osman A, Hassouna A, Motawea I. Novel non-invasive biological predictive index for liver fibrosis in hepatitis C virus genotype 4 patients. World J Hepatol 2016; 8(32): 1392-1401
URL	http://www.wjgnet.com/1948-5182/full/v8/i32/1392.htm
DOI	http://dx.doi.org/10.4254/wjh.v8.i32.1392

Full Article (PDF)	WJH-8-1392.pdf
Full Article (Word)	WJH-8-1392.doc