| ISSN |
1948-5182 (online) |
| Open Access |
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2016. Published by Baishideng Publishing Group Inc. All rights reserved.
|
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Gastroenterology & Hepatology |
| Manuscript Type |
Observational Study |
| Article Title |
Novel non-invasive biological predictive index for liver fibrosis in hepatitis C virus genotype 4 patients
|
| Manuscript Source |
Invited Manuscript |
| All Author List |
Mahmoud Khattab, Mohamed Amin Sakr, Mohamed Abdel Fattah, Youssef Mousa, Elwy Soliman, Ashraf Breedy, Mona Fathi, Salwa Gaber, Ahmed Altaweil, Ashraf Osman, Ahmed Hassouna and Ibrahim Motawea |
| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| Governmental Foundation Scientific and Technology Development Foundation |
1538 |
|
| Corresponding Author |
Mahmoud Khattab, MD, PhD, Professor of Medicine, Head of Liver Unit, Department of Internal Medicine, Minia University, Cornish Al Nile Road, Minia 61111, Egypt. mkhattabmed@hotmail.com |
| Key Words |
Liver fibrosis; Insulin resistance; Aspartate amino transaminase; Platelets; Age |
| Core Tip |
This observational study included a cohort of 332 recruited patients with hepatitis C virus (HCV) genotype 4 infections. The study assessed the status of demographic and biological variables at different stages of liver fibrosis. Liver biopsy with Metavir scoring was the reference standard used to classify patients into five stages of liver fibrosis (F0-F4). Patient regrouping to include three levels of fibrosis, mild (F0-F1), moderate (F2), and advanced (F3-F4), was performed to conform with practical guidelines for the management and follow-up of HCV patients. Age, aspartate transaminase enzyme (AST), insulin resistance (HOMA-IR), and platelet count were significant predictors of liver fibrosis as shown on univariate analysis. Log AST, log HOMA-IR, log platelet count and age were introduced into stepwise multivariate discriminative analysis, and a model for the prediction of liver fibrosis level was derived. Our pre-dictive index exhibited an area under the curve (AUC) of 0.91 for the diagnosis of advanced stages of fibrosis and an AUC of 0.88 for the diagnosis of mild stages of fibrosis. The index exhibited a lower AUC of 0.64 in the diagnosis of moderate stages of fibrosis. |
| Publish Date |
2016-11-16 10:47 |
| Citation |
Khattab M, Sakr MA, Fattah MA, Mousa Y, Soliman E, Breedy A, Fathi M, Gaber S, Altaweil A, Osman A, Hassouna A, Motawea I. Novel non-invasive biological predictive index for liver fibrosis in hepatitis C virus genotype 4 patients. World J Hepatol 2016; 8(32): 1392-1401 |
| URL |
http://www.wjgnet.com/1948-5182/full/v8/i32/1392.htm |
| DOI |
http://dx.doi.org/10.4254/wjh.v8.i32.1392 |
