| ISSN |
2220-3206 (online) |
| Open Access |
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2016. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
|
| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
|
| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Allergy |
| Manuscript Type |
Retrospective Study |
| Article Title |
Infectious, atopic and inflammatory diseases, childhood adversities and familial aggregation are independently associated with the risk for mental disorders: Results from a large Swiss epidemiological study
|
| Manuscript Source |
Invited Manuscript |
| All Author List |
Vladeta Ajdacic-Gross, Aleksandra Aleksandrowicz, Stephanie Rodgers, Margot Mutsch, Anja Tesic, Mario Müller, Wolfram Kawohl, Wulf Rössler, Erich Seifritz, Enrique Castelao, Marie-Pierre F Strippoli, Caroline Vandeleur, Roland von Känel, Rosa Paolicelli, Markus A Landolt, Cornelia Witthauer, Roselind Lieb and Martin Preisig |
| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| Swiss National Science Foundation |
3200B0–105993 |
| Swiss National Science Foundation |
3200B0-118308 |
| Swiss National Science Foundation |
33CSCO-122661 |
| Swiss National Science Foundation |
33CS30-139468 |
| Swiss National Science Foundation |
33CS30-148401 |
| Faculty of Biology and Medicine of Lausanne |
|
| GlaxoSmithKline |
|
|
| Corresponding Author |
Vladeta Ajdacic-Gross, PhD, Department of Psychiatry, Psychotherapy and Psychosomatics, Psychiatric Hospital, University of Zurich, PO Box 2019, 8021 Zurich, Switzerland. vajdacic@dgsp.uzh.ch
|
| Key Words |
Neurodevelopmental disorders; Mental disorders; Substance abuse; Childhood diseases; Infectious diseases; Atopic diseases; Chronic inflammatory diseases; Risk factors |
| Core Tip |
This study adds to the evidence that infectious, atopic and inflammatory diseases make up an important group of risk factors for neurodevelopmental and common mental disorders. They contribute independently of further major risk factors such as childhood adversities, traumatic experiences and familial aggregation. Each group of mental disorders (neurodevelopmental, early and late anxiety, mood, substance) attracts different combinations of risk factors. The sexual dimorphism of the associations is pronounced. The hypothesized biological mechanism that acts as a common denominator in this group of risk factors involves imbalances, e.g., within the development of the immune system interfering with critical stages of brain development.
|
| Publish Date |
2016-12-20 19:15 |
| Citation |
Ajdacic-Gross V, Aleksandrowicz A, Rodgers S, Mutsch M, Tesic A, Müller M, Kawohl W, Rössler W, Seifritz E, Castelao E, Strippoli MPF, Vandeleur C, von Känel R, Paolicelli R, Landolt MA, Witthauer C, Lieb R, Preisig M. Infectious, atopic and inflammatory diseases, childhood adversities and familial aggregation are independently associated with the risk for mental disorders: Results from a large Swiss epidemiological study. World J Psychiatr 2016; 6(4): 419-430 |
| URL |
http://www.wjgnet.com/2220-3206/full/v6/i4/419.htm |
| DOI |
http://dx.doi.org/10.5498/wjp.v6.i4.419 |
