Publication Name	World Journal of Critical Care Medicine
Manuscript ID	28314
Country	Belgium

Received	2016-06-29 16:28
Peer-Review Started	2016-07-01 14:37
To Make the First Decision	2016-09-05 09:06
Return for Revision	2016-09-05 15:52
Revised	2016-09-27 23:44
Second Decision	2016-11-01 09:46
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief	2016-11-17 14:12
Articles in Press	2016-11-17 14:12
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2017-01-13 08:39
Publish the Manuscript Online	2017-01-22 18:57

ISSN	2220-3141(online)
Open Access	This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
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Category	Critical Care Medicine
Manuscript Type	Minireviews
Article Title	Exertional rhabdomyolysis and heat stroke: Beware of volatile anesthetic sedation
Manuscript Source	Invited Manuscript
All Author List	Karel Heytens, Jan De Bleecker, Walter Verbrugghe, Jonathan Baets and Luc Heytens
Funding Agency and Grant Number
Corresponding Author	Luc Heytens, MD, PhD, MH Research Unit, University of Antwerp, Campus Drie Eiken, 2610 Wilrijk, Belgium. luc.heytens@uantwerpen.be
Key Words	Exertional rhabdomyolysis; Heat stroke; Intensive care sedation; Inhalational anesthetics; Malignant hyperthermia; Congenital myopathies
Core Tip	Recent research has shown that a substantial proportion of patients with exercise-induced heatstroke harbor mutations in the ryanodine-receptor one gene on Chromosome 19 (RYR1), encoding for the principal calcium-release channel in striated muscle. These same mutations are known to result in a massively increased calcium-conductivity and life-threatening rhabdomyolysis when malignant hyperthermia (MH) susceptible patients are exposed to volatile anesthetics during general anesthesia. In view of this, exposure to volatile anesthetic sedation - an emerging trend in intensive care units - is contraindicated, not only in patients with known MH susceptibility and other congenital myopathies, but also in patients admitted because of exertional rhabdomyolysis and heatstroke.
Publish Date	2017-01-22 18:57
Citation	Heytens K, De Bleecker J, Verbrugghe W, Baets J, Heytens L. Exertional rhabdomyolysis and heat stroke: Beware of volatile anesthetic sedation. World J Crit Care Med 2017; 6(1): 21-27
URL	http://www.wjgnet.com/2220-3141/full/v6/i1/21.htm
DOI	http://dx.doi.org/10.5492/wjccm.v6.i1.21

Full Article (PDF)	WJCCM-6-21.pdf
Full Article (Word)	WJCCM-6-21.doc
Manuscript File	28314-Review.docx
Answering Reviewers	28314-Answering reviewers.pdf
Audio Core Tip	28314-Audio core tip.mp3
Conflict-of-Interest Disclosure Form	28314-Conflict-of-interest statement.pdf
Copyright License Agreement	28314-Copyright assignment.pdf
Non-Native Speakers of English Editing Certificate	28314-Language certificate.pdf
Supplementary Material	Supplementary_Material_20160628222935.pdf
Peer-review Report	28314-Peer-review(s).pdf
Scientific Misconduct Check	28314-Scientific misconduct check.pdf
Scientific Editor Work List	28314-Scientific editor work list.pdf