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Articles Published Processes
12/28/2016 3:41:00 PM | Browse: 1342 | Download: 2327
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Received |
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2016-06-30 09:28 |
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Peer-Review Started |
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2016-07-01 19:15 |
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First Decision by Editorial Office Director |
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Return for Revision |
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2016-09-05 16:14 |
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Revised |
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2016-09-14 16:30 |
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Publication Fee Transferred |
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Second Decision by Editor |
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2016-10-10 09:34 |
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Second Decision by Editor-in-Chief |
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2016-10-11 22:45 |
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Final Decision by Editorial Office Director |
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2016-10-24 14:43 |
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Articles in Press |
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2016-10-24 14:43 |
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Edit the Manuscript by Language Editor |
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Typeset the Manuscript |
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2016-12-26 13:13 |
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Publish the Manuscript Online |
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2016-12-28 15:40 |
| ISSN |
2220-6124 (online) |
| Open Access |
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2017. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Developmental Biology |
| Manuscript Type |
Basic Study |
| Article Title |
Acetylsalicylic acid interferes with embryonic kidney growth and development by a prostaglandin-independent mechanism
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| Manuscript Source |
Invited Manuscript |
| All Author List |
Simon JM Welham, Alexander J Sparrow, David S Gardner and Matthew J Elmes |
| Funding Agency and Grant Number |
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| Corresponding Author |
Dr. Simon JM Welham, Division of Nutritional Sciences, School of Biosciences, University of Nottingham, Sutton Bonington Campus, Loughborough, Leicestershire LE12 5RD, United Kingdom. simon.welham@nottingham.ac.uk |
| Key Words |
Acetylsalicylic acid; Nephrogenesis; Kidney culture; Non-steroidal anti-inflammatory drug; Prostaglandins; Prostaglandin synthase 2 |
| Core Tip |
Non-steroidal anti-inflammatory drugs (NSAIDs) are widely used as painkillers and are available without prescription. They act by inhibiting cyclooxygenase activity thereby preventing prostaglandin synthesis via the prostaglandin synthase enzymes prostaglandin synthase 1 (PTGS1) and PTGS2. Although NSAIDs cross the placenta, they are among the most common drugs prescribed during the first trimester of pregnancy and estimated prevalence of usage is more than 25% of pregnant women. NSAID use during pregnancy has been associated with abnormal renal development and renal failure in the offspring at birth. These may impact the individual throughout their adult life. |
| Publish Date |
2016-12-28 15:40 |
| Citation |
Welham SJM, Sparrow AJ, Gardner DS, Elmes MJ. Acetylsalicylic acid interferes with embryonic kidney growth and development by a prostaglandin-independent mechanism. World J Nephrol 2017; 6(1): 21-28 |
| URL |
http://www.wjgnet.com/2220-6124/full/v6/i1/21.htm |
| DOI |
http://dx.doi.org/10.5527/wjn.v6.i1.21 |
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