Publication Name	World Journal of Hepatology
Manuscript ID	28415
Country	United States

Received	2016-06-30 09:19
Peer-Review Started	2016-06-30 15:49
To Make the First Decision	2016-08-18 10:02
Return for Revision	2016-08-19 15:58
Revised	2016-09-20 02:40
Second Decision	2016-10-13 12:15
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2016-10-24 15:23
Articles in Press	2016-10-24 15:23
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2016-12-05 10:49
Publish the Manuscript Online	2017-01-06 08:51

ISSN	1948-5182 (online)
Open Access	This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
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Category	Gastroenterology & Hepatology
Manuscript Type	Review
Article Title	Disease monitoring of hepatocellular carcinoma through metabolomics
Manuscript Source	Invited Manuscript
All Author List	Asem I Fitian and Roniel Cabrera
Funding Agency and Grant Number
Corresponding Author	Roniel Cabrera, MD, MS, Department of Medicine, Division of Gastroen­terology, Hepatology and Nutrition, Section of Hepatobiliary Diseases, University of Florida, 1600 SW Archer Rd M440, Gainesville, FL 32610, United States. roniel.cabrera@medicine.ufl.edu
Key Words	Metabolomics; Hepatocellular carcinoma; Biomarkers; Metabolic profiling; Chromatography/mass spectrometry; Noninvasive biomarkers; Cirrhosis
Core Tip	The high-throughput, validated nature of meta-bolomics makes it an ideal methodology for rapidly identifying the global metabolic alterations associated with hepatocarcinogenesis - alterations that not only enhance our understanding of the metabolic under-pinnings of cirrhosis and hepatocellular carcinoma (HCC), but that can be leveraged to improve HCC diagnostic, therapeutic, and disease monitoring efficacy. Indeed, contemporary HCC metabolomics works time and again demonstrate this promise that metabolomics platforms hold in serving as standalone non-invasive HCC diag-nostic and disease monitoring modalities.
Publish Date	2017-01-06 08:51
Citation	Fitian AI, Cabrera R. Disease monitoring of hepatocellular carcinoma through metabolomics. World J Hepatol 2017; 9(1): 1-17
URL	http://www.wjgnet.com/1948-5182/full/v9/i1/1.htm
DOI	http://dx.doi.org/10.4254/wjh.v9.i1.1

Full Article (PDF)	WJH-9-1.pdf
Full Article (Word)	WJH-9-1.doc
Manuscript File	28415-Review.docx
Answering Reviewers	28415-Answering reviewers.pdf
Audio Core Tip	28415-Audio core tip.mp3
Conflict-of-Interest Disclosure Form	28415-Conflict-of-interest statement.pdf
Copyright License Agreement	28415-Copyright assignment.pdf
Peer-review Report	28415-Peer-review(s).pdf
Scientific Misconduct Check	28415-Scientific misconduct check.pdf
Scientific Editor Work List	28415-Scientific editor work list.pdf