Publication Name	World Journal of Hepatology
Manuscript ID	28451
Country	United Kingdom

Received	2016-07-01 09:24
Peer-Review Started	2016-07-03 14:57
First Decision by Editorial Office Director
Return for Revision	2016-08-05 12:08
Revised	2016-09-16 04:03
Publication Fee Transferred
Second Decision by Editor	2016-10-28 11:20
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director	2016-11-02 16:14
Articles in Press	2016-11-02 16:14
Edit the Manuscript by Language Editor
Typeset the Manuscript	2016-12-19 08:43
Publish the Manuscript Online	2016-12-27 08:31

ISSN	1948-5182 (online)
Open Access	This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
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Category	Gastroenterology & Hepatology
Manuscript Type	Observational Study
Article Title	Prevalence of significant liver disease in human immunodeficiency virus-infected patients exposed to Didanosine: A cross sectional study
Manuscript Source	Invited Manuscript
All Author List	Sarah Logan, Alison Rodger, Laura Maynard-Smith, James O’Beirne, Thomas Fernandez, Filippo Ferro, Colette Smith and Sanjay Bhagani
Funding Agency and Grant Number	Funding Agency Grant Number British HIV Association Research Award 2009-£7800 in total awarded
Corresponding Author	Dr. Sanjay Bhagani, Consultant in Infectious Diseases and HIV Medicine, the Ian Charleson Day Centre, Ground Floor, Royal Free London NHS Foundation Trust, Rowland Hill Street, London NW3 2PF, United Kingdom. s.bhagani@nhs.net
Key Words	Nodular regenerative hyperplasia; Human immunodeficiency virus; Steatosis; Non-cirrhotic portal hypertension; Didanosine
Core Tip	Human immunodeficiency virus positive pa-tients are at increased risk of liver disease. The aetio-logy is often multifactorial and includes exposure to antiretroviral therapy. We used a simple screening stra-tegy based on transient elastography, liver enzymes and ultrasound scan to identify that 2% of asymptomatic patients exposed to Didanosine in a clinical cohort had undiagnosed nodular regenerative hyperplasia. A further 6% had undiagnosed steatosis. Implementation of a screening strategy enables identification of liver disease and initiation of earlier targeted interventions in this high-risk group.
Publish Date	2016-12-27 08:31
Citation	Logan S, Rodger A, Maynard-Smith L, O’Beirne J, Fernandez T, Ferro F, Smith C, Bhagani S. Prevalence of significant liver disease in human immunodeficiency virus-infected patients exposed to Didanosine: A cross sectional study. World J Hepatol 2016; 8(36): 1623-1628
URL	http://www.wjgnet.com/1948-5182/full/v8/i36/1623.htm
DOI	http://dx.doi.org/10.4254/wjh.v8.i36.1623

Full Article (PDF)	WJH-8-1623.pdf
Full Article (Word)	WJH-8-1623.doc