Publication Name	World Journal of Stem Cells
Manuscript ID	28532
Country	Japan

Received	2016-07-05 10:35
Peer-Review Started	2016-07-12 11:58
To Make the First Decision	2016-08-05 15:30
Return for Revision	2016-08-11 16:27
Revised	2016-08-22 10:45
Second Decision	2016-09-26 15:41
Accepted by Journal Editor-in-Chief	2016-09-27 10:50
Accepted by Company Editor-in-Chief	2016-10-09 10:50
Articles in Press	2016-10-09 10:50
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2017-01-06 13:50
Publish the Manuscript Online	2017-01-18 15:19

ISSN	1948-0210 (online)
Open Access	This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright	© The Author(s) 2017. Published by Baishideng Publishing Group Inc. All rights reserved.
Article Reprints	For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
Permissions	For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher	Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website	http://www.wjgnet.com

Category	Cell Biology
Manuscript Type	Editorial
Article Title	Preventing aging with stem cell rejuvenation: Feasible or infeasible?
Manuscript Source	Invited Manuscript
All Author List	Kanya Honoki
Funding Agency and Grant Number	Funding Agency Grant Number Ministry of Education, Culture, Sports, Science and Technology in Japan No. 15K10455
Corresponding Author	Kanya Honoki, MD, PhD, MMedSci, Associate Professor, Department of Orthopedic Surgery, Nara Medical University, 840 Shijo-cho, Kashihara, Nara 634-8521, Japan. kahonoki@naramed-u.ac.jp
Key Words	Aging; Stem cell; Niche; Rejuvenation; Sig­naling pathway
Core Tip	Functional loss of stem cells plays an important role in organismic aging processes. Recent advances in aging research have uncovered the molecular mechanisms of aging, specifically signaling pathways involved in interactions between stem cells and their environment, the so-called “stem cell niche”. Investigating plasma fraction factors has revealed several key pathways involved in this process, including Notch/Delta, Wnt, transforming growth factor-β, JAK/STAT, mammalian target of rapamycin and p38 mitogen-activated protein kinase signaling. Stem cell rejuvenation has the potential to lead organismic rejuvenation by modulating these pathways, hopefully by synthetic or natural agents such as phytochemicals and flavonoids.
Publish Date	2017-01-18 15:19
Citation	Honoki K. Preventing aging with stem cell rejuvenation: Feasible or infeasible? World J Stem Cells 2017; 9(1): 1-8
URL	http://www.wjgnet.com/1948-0210/full/v9/i1/1.htm
DOI	http://dx.doi.org/10.4252/wjsc.v9.i1.1

Full Article (PDF)	WJSC-9-1.pdf
Full Article (Word)	WJSC-9-1.doc
Manuscript File	28532-Review.docx
Answering Reviewers	28532-Answering reviewers.pdf
Audio Core Tip	28532-Audio core tip.MP3
Conflict-of-Interest Disclosure Form	28532-Conflict-of-interest statement.pdf
Copyright License Agreement	28532-Copyright assignment.pdf
Approved Grant Application Form(s) or Funding Agency Copy of any Approval Document(s)	28532-Grant application form(s).pdf
Non-Native Speakers of English Editing Certificate	28532-Language certificate.pdf
Supplementary Material	Supplementary_Material_20160704094351.pdf
Peer-review Report	28532-Peer-review(s).pdf
Journal Editor-in-Chief Review Report	28532-Journal editor-in-chief review report.pdf
Scientific Misconduct Check	28532-Scientific misconduct check.pdf
Scientific Editor Work List	28532-Scientific editor work list.pdf