Publication Name	World Journal of Diabetes
Manuscript ID	28589
Country	United States

Received	2016-07-06 09:34
Peer-Review Started	2016-07-12 18:33
To Make the First Decision	2016-09-06 10:59
Return for Revision	2016-09-12 10:46
Revised	2016-09-24 01:05
Second Decision	2016-11-10 14:20
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2016-11-22 15:28
Articles in Press	2016-11-22 15:28
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2017-02-12 21:51
Publish the Manuscript Online	2017-02-15 11:49

ISSN	1948-9358 (online)
Open Access	This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright	© The Author(s) 2017. Published by Baishideng Publishing Group Inc. All rights reserved.
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Category	Neurosciences
Manuscript Type	Review
Article Title	Integrating insulin-like growth factor 1 and sex hormones into neuroprotection: Implications for diabetes
Manuscript Source	Invited Manuscript
All Author List	Integrating insulin-like growth factor 1 and sex hormones into neuroprotection: Implications for diabetes
Funding Agency and Grant Number
Corresponding Author	George T Taylor, PhD, Professor, Behavioral Neuroscience Program, Department of Psychological Sciences, University of Missouri, 1 University Blvd, St. Louis, MO 63121, United States. geot@umsl.edu
Key Words	Diabetes; Androgens; Estrogen; Insulin; Insulin-like growth factor 1; Neuroprotection; Brain integrity; Cognition
Core Tip	Insulin-like growth factor 1 (IGF1), estrogen, and androgens are known to have neuroprotective properties. Fluctuations in these hormones is observed in patients with diabetes, varies with sex, and may contribute to abnormalities in brain integrity and cogni-tive impairment typical of the disease. While the neuro-protective coupling of estrogen and IGF1 has been studied extensively, little research has focused similarly on androgens. Furthermore, research investigating the IGF1-sex hormones relation to diabetes and brain-health outcomes is minimal. One avenue of approach to extend this literature may be to examine sex differences by comparison of these hormone levels, brain integrity, and cognitive aptitude.
Publish Date	2017-02-15 11:49
Citation	Huffman J, Hoffmann C, Taylor GT. Integrating insulin-like growth factor 1 and sex hormones into neuroprotection: Implications for diabetes. World J Diabetes 2017; 8(2): 45-55
URL	http://www.wjgnet.com/1948-9358/full/v8/i2/45.htm
DOI	http://dx.doi.org/10.4239/wjd.v8.i2.45

Full Article (PDF)	WJD-8-45.pdf
Full Article (Word)	WJD-8-45.doc
Manuscript File	28589-Review.docx
Answering Reviewers	28589-Answering reviewers.pdf
Audio Core Tip	28589-Audio core tip.MP3
Conflict-of-Interest Disclosure Form	28589-Conflict-of-interest statement.pdf
Copyright License Agreement	28589-Copyright assignment.pdf
Peer-review Report	28589-Peer-review(s).pdf
Scientific Misconduct Check	28589-Scientific misconduct check.pdf
Scientific Editor Work List	28589-Scientific editor work list.pdf