Publication Name	World Journal of Transplantation
Manuscript ID	28592
Country	United States

Received	2016-07-07 09:34
Peer-Review Started	2016-07-12 18:47
To Make the First Decision	2016-09-06 11:00
Return for Revision	2016-09-12 11:04
Revised	2016-09-23 04:37
Second Decision	2016-11-10 14:22
Accepted by Journal Editor-in-Chief	2016-11-10 21:28
Accepted by Executive Editor-in-Chief	2016-11-22 15:30
Articles in Press	2016-11-22 15:30
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2016-12-05 14:31
Publish the Manuscript Online	2016-12-14 14:32

ISSN	2220-3230 (online)
Open Access	This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright	© The Author(s) 2016. Published by Baishideng Publishing Group Inc. All rights reserved.
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Category	Transplantation
Manuscript Type	Observational Study
Article Title	Persistent Epstein-Barr viral load in Epstein-Barr viral naïve pediatric heart transplant recipients: Risk of late-onset post-transplant lymphoproliferative disease
Manuscript Source	Invited Manuscript
All Author List	Bibhuti Das, Robert Morrow, Rong Huang and David Fixler
Funding Agency and Grant Number
Corresponding Author	Bibhuti Das, MD, Deptartment of Pediatrics, Children’s Medical Center, University of Texas Southwestern Medical Center, 1935 Medical District Dr, Dallas, TX 75235, United States. bdas99@hotmail.com
Key Words	Pediatric heart transplantation; Epstein-Barr virus; Post-transplant lymphoproliferative disorder; Immunosuppression; Allograft rejection
Core Tip	Post-transplant lymphoproliferative disorder (PTLD) after heart transplantation is a severe complication where there is still limited information is available. There are many publications on estimations of PTLD frequency in different settings and types of patient, as well as the factors associated with its appearance and prognosis. But, most studies do not take into account the length of follow-up which may be misleading given that patients are exposed to the risk of immunosuppression over a long period of follow-up. This study is unique that, it is a single center study span over a period of 18 years in which maintenance immunosuppression therapy and management of rejection episodes remained same throughout. Although, a single center study result cannot be generalized, however it adds to the existing literature for risk stratification of these patients based on whole blood Epstein-Barr virus (EBV) polymerase chain reaction (PCR) after accounting for the time since transplant and patients’ pre-transplant EBV serostatus. This paper also highlights the risk of acute rejection after reduction or alteration in immunosuppression in patients with high EBV load by PCR without any effect on the occurrence of PTLD.
Publish Date	2016-12-14 14:32
Citation	Das B, Morrow R, Huang R, Fixler D. Persistent Epstein-Barr viral load in Epstein-Barr viral naïve pediatric heart transplant recipients: Risk of late-onset post-transplant lymphoproliferative disease. World J Transplant 2016; 6(4): 729-735
URL	http://www.wjgnet.com/2220-3230/full/v6/i4/729.htm
DOI	http://dx.doi.org/10.5500/wjt.v6.i4.729

Full Article (PDF)	WJT-6-729.pdf
Full Article (Word)	WJT-6-729.doc
Manuscript File	28592-Review.docx
Answering Reviewers	28592-Answering reviewers.pdf
Audio Core Tip	28592-Audio core tip.mp3
Biostatistics Review Certificate	28592-Biostatistics statement.pdf
Conflict-of-Interest Disclosure Form	28592-Conflict-of-interest statement.pdf
Copyright License Agreement	28592-Copyright assignment.pdf
Signed Informed Consent Form(s) or Document(s)	Informed_Consent_Statement_20160706040140.pdf
Institutional Review Board Approval Form or Document	28592-Institutional review board statement.pdf
Peer-review Report	28592-Peer-review(s).pdf
Journal Editor-in-Chief Review Report	28592-Journal editor-in-chief review report.pdf
Scientific Misconduct Check	28592-Scientific misconduct check.pdf
Scientific Editor Work List	28592-Scientific editor work list.pdf