Publication Name	World Journal of Gastroenterology
Manuscript ID	28692
Country	United States

Received	2016-07-11 08:44
Peer-Review Started	2016-07-13 16:21
To Make the First Decision	2016-08-19 10:55
Return for Revision	2016-08-23 10:19
Revised	2016-08-31 07:59
Second Decision	2016-09-05 18:43
Accepted by Journal Editor-in-Chief	2016-09-05 19:58
Accepted by Company Editor-in-Chief	2016-09-12 16:12
Articles in Press	2016-09-12 16:13
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2016-09-29 11:56
Publish the Manuscript Online	2016-10-12 14:18

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access	This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright	© The Author(s) 2016. Published by Baishideng Publishing Group Inc. All rights reserved.
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Category	Gastroenterology & Hepatology
Manuscript Type	Case Report
Article Title	Limited, local, extracolonic spread of mucinous appendiceal adenocarcinoma after perforation with formation of a malignant appendix-to-sigmoid fistula: Case report and literature review
Manuscript Source	Invited Manuscript
All Author List	Seifeldin Hakim, Mitual Amin and Mitchell S Cappell
Funding Agency and Grant Number
Corresponding Author	Mitchell S Cappell, MD, PhD, Chief, Division of Gastroenterology and Hepatology, Department of Internal Medicine, William Beaumont Hospital, MOB #602, 3535 West Thirteen Mile Road, Royal Oak, MI 48073, United States. mscappell@yahoo.com
Key Words	Mucinous adenocarcinoma; Appendicitis; Appendix; Malignant fistula; Pseudomyxoma peritonei; Colon cancer; Metastases
Core Tip	A patient with mucinous appendiceal adenocarcinoma had appendiceal perforation that was locally contained by a malignant appendix-to-sigmoid fistula. The patient presented with right lower quadrant pain and tenderness and constipation. Abdomino-pelvic computed tomography and magnetic resonance imaging revealed a bulky peri-appendiceal mass containing an appendix-to-sigmoid-fistula. Pathologic analysis after debulking surgery revealed a locally extensive cancer involving appendix, sigmoid, and cecum and extending up to adjacent viscera with clear surgical margins and benign lymph nodes. The patient remained free of local recurrence/metastases during 1 year of follow-up despite not receiving chemotherapy/radiotherapy. This apparently favorable outcome is due to this cancer’s nonaggressive biology, and the fistula which likely largely contained cancer cell spillage within the colon and prevented free cancer cell spillage.
Publish Date	2016-10-12 14:18
Citation	Hakim S, Amin M, Cappell MS. Limited, local, extracolonic spread of mucinous appendiceal adenocarcinoma after perforation with formation of a malignant appendix-to-sigmoid fistula: Case report and literature review. World J Gastroenterol 2016; 22(38): 8624-8630
URL	http://www.wjgnet.com/1007-9327/full/v22/i38/8624.htm
DOI	http://dx.doi.org/10.3748/wjg.v22.i38.8624

Full Article (PDF)	WJG-22-8624.pdf
Full Article (Word)	WJG-22-8624.doc
Manuscript File	28692-Review.docx
Answering Reviewers	28692-Answering reviewers.pdf
Audio Core Tip	28692-Audio core tip.mp3
Conflict-of-Interest Disclosure Form	28692-Conflict-of-interest statement.pdf
Copyright License Agreement	28692-Copyright assignment.pdf
Institutional Review Board Approval Form or Document	28692-Institutional review board statement.pdf
Peer-review Report	28692-Peer-review(s).pdf
Journal Editor-in-Chief Review Report	28692-Journal editor-in-chief review report.pdf
Scientific Misconduct Check	28692-Scientific misconduct check.pdf
Scientific Editor Work List	28692-Scientific editor work list.pdf