Publication Name	World Journal of Transplantation
Manuscript ID	28693
Country	United States

Received	2016-07-11 08:41
Peer-Review Started	2016-07-11 17:24
To Make the First Decision	2016-09-30 11:20
Return for Revision	2016-09-30 14:22
Revised	2016-10-03 21:24
Second Decision	2016-10-21 10:17
Accepted by Journal Editor-in-Chief	2016-10-24 20:11
Accepted by Executive Editor-in-Chief	2016-11-02 16:29
Articles in Press	2016-11-02 16:30
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2016-12-05 14:31
Publish the Manuscript Online	2016-12-14 14:32

ISSN	2220-3230 (online)
Open Access	This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright	© The Author(s) 2016. Published by Baishideng Publishing Group Inc. All rights reserved.
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Category	Transplantation
Manuscript Type	Minireviews
Article Title	More than skin deep? Potential nicotinamide treatment applications in chronic kidney transplant recipients
Manuscript Source	Unsolicited Manuscript
All Author List	Andrew G Bostom, Basma Merhi, Joanna Walker and Leslie Robinson-Bostom
Funding Agency and Grant Number
Corresponding Author	Andrew G Bostom, MD, MS, Associate Professor of Medicine, Research Physician, Division of Hypertension and Kidney Diseases, Department of Medicine, Rhode Island Hospital, 593 Eddy Street, Providence, RI 02903, United States. abostom@cox.net
Key Words	Kidney transplantation; Skin neoplasms; Niacinamide; Phosphorus
Core Tip	Our unique review describes promising evidence that oral nicotinamide may have dual therapeutic clinical applications in chronic kidney transplant recipients (KTRs). First, nicotinamide, via its inhibition of sirtuin-mediated enzymatic pathways, may reduce the rate of KTR non-melanoma skin cancers. Second, nicotinamide’s hypophosphatemic effect could lower the rate of cardiorenal outcomes in KTRs. These hypothesized benefits warrant further study in randomized, placebo-controlled trials of nicotinamide treatment with both intermediate, and eventually, hard clinical outcomes.
Publish Date	2016-12-14 14:32
Citation	Bostom AG, Merhi B, Walker J, Robinson-Bostom L. More than skin deep? Potential nicotinamide treatment applications in chronic kidney transplant recipients. World J Transplant 2016; 6(4): 658-664
URL	http://www.wjgnet.com/2220-3230/full/v6/i4/658.htm
DOI	http://dx.doi.org/10.5500/wjt.v6.i4.658

Full Article (PDF)	WJT-6-658.pdf
Full Article (Word)	WJT-6-658.doc
Manuscript File	28693-Review.docx
Answering Reviewers	28693-Answering reviewers.pdf
Audio Core Tip	28693-Audio core tip.mp3
Conflict-of-Interest Disclosure Form	28693-Conflict-of-interest statement.pdf
Copyright License Agreement	28693-Copyright assignment.pdf
Peer-review Report	28693-Peer-review(s).pdf
Journal Editor-in-Chief Review Report	28693-Journal editor-in-chief review report.pdf
Scientific Misconduct Check	28693-Scientific misconduct check.pdf
Scientific Editor Work List	28693-Scientific editor work list.pdf