Publication Name	World Journal of Gastroenterology
Manuscript ID	28905
Country	China

Received	2016-07-22 09:10
Peer-Review Started	2016-07-22 11:02
First Decision by Editorial Office Director
Return for Revision	2016-08-23 09:20
Revised	2016-08-29 16:04
Publication Fee Transferred
Second Decision by Editor	2016-09-11 11:27
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director	2016-09-14 13:38
Articles in Press	2016-09-14 13:39
Edit the Manuscript by Language Editor	2016-09-29 12:08
Typeset the Manuscript	2016-11-17 16:17
Publish the Manuscript Online	2016-11-26 18:57

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access	This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright	© The Author(s) 2016. Published by Baishideng Publishing Group Inc. All rights reserved.
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Category	Gastroenterology & Hepatology
Manuscript Type	Observational Study
Article Title	Disease-specific miR-34a as diagnostic marker of non-alcoholic steatohepatitis in a Chinese population
Manuscript Source	Unsolicited Manuscript
All Author List	Xiao-Lin Liu, Qin Pan, Rui-Nan Zhang, Feng Shen, Shi-Yan Yan, Chao Sun, Zheng-Jie Xu, Yuan-Wen Chen and Jian-Gao Fan
Funding Agency and Grant Number	Funding Agency Grant Number State Key Development Program for Basic Research of China 2012CB517501 National Natural Science Foundation of China 81270491 Hundred Talents Program of the Shanghai Board of Health XBR2011007 Program of the Shanghai Committee of Science and Technology 10411956300 National Natural Science Foundation of China 81470840
Corresponding Author	Jian-Gao Fan, Professor, Center for Fatty Liver, Department of Gastroenterology, Xin Hua Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, 1665 Kongjiang Road, Shanghai 200092, China. fattyliver2004@126.com
Key Words	MicroRNA; Non-alcoholic steatohepatitis; Hepatic fibrosis; Biomarker; Chronic hepatitis B
Core Tip	Circulating miR-122, -192, -34a and -16 showed differential expression levels between non-alcoholic fatty liver disease and chronic hepatitis B patients, and serum miR-122, -192 and -34a could also differentiate non-alcoholic steatohepatitis (NASH) from non-alcoholic fatty liver. The latter were correlated with steatosis and inflammatory activity, and only serum miR-16 was associated with hepatic fibrosis. The diagnostic value of miR-34a for NASH was superior to that of alanine aminotransferase and cytokeratin-18, but miR-16 showed a slightly poorer performance than that of fibrosis-4 and aspartate aminotransferase to platelet ratio index in the diagnosis of significant fibrosis in NASH.
Publish Date	2016-11-26 18:57
Citation	Liu XL, Pan Q, Zhang RN, Shen F, Yan SY, Sun C, Xu ZJ, Chen YW, Fan JG. Disease-specific miR-34a as diagnostic marker of non-alcoholic steatohepatitis in a Chinese population. World J Gastroenterol 2016; 22(44): 9844-9852
URL	http://www.wjgnet.com/1007-9327/full/v22/i44/9844.htm
DOI	http://dx.doi.org/10.3748/wjg.v22.i44.9844

Full Article (PDF)	WJG-22-9844.pdf
Full Article (Word)	WJG-22-9844.doc
Manuscript File	28905-Review.docx
Answering Reviewers	28905-Answering reviewers.pdf
Audio Core Tip	28905-Audio core tip.mp3
Biostatistics Review Certificate	Biostatistics_Statement_20160721151042.pdf
Conflict-of-Interest Disclosure Form	28905-Conflict-of-interest statement.pdf
Copyright License Agreement	28905-Copyright assignment.pdf
Signed Informed Consent Form(s) or Document(s)	Informed_Consent_Statement_20160721151046.pdf
Institutional Review Board Approval Form or Document	28905-Institutional review board statement.pdf
Non-Native Speakers of English Editing Certificate	Editing_Certificate_20160721151114.pdf
Peer-review Report	28905-Peer-review(s).pdf
Scientific Misconduct Check	28905-Scientific misconduct check.pdf
Scientific Editor Work List	28905-Scientific editor work list.pdf