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11/26/2016 6:56:00 PM | Browse: 462 | Download: 659
Publication Name World Journal of Gastroenterology
Manuscript ID 28905
Country/Territory China
Received
2016-07-22 09:10
Peer-Review Started
2016-07-22 11:02
To Make the First Decision
2016-08-22 15:08
Return for Revision
2016-08-23 09:20
Revised
2016-08-29 16:04
Second Decision
2016-09-11 11:27
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief
2016-09-14 13:38
Articles in Press
2016-09-14 13:39
Publication Fee Transferred
Edit the Manuscript by Language Editor
2016-09-29 12:08
Typeset the Manuscript
2016-11-17 16:17
Publish the Manuscript Online
2016-11-26 18:57
ISSN 1007-9327 (print) and 2219-2840 (online)
Open Access This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright © The Author(s) 2016. Published by Baishideng Publishing Group Inc. All rights reserved.
Article Reprints For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
Permissions For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website http://www.wjgnet.com
Category Gastroenterology and Hepatology
Manuscript Type Observational Study
Article Title Disease-specific miR-34a as diagnostic marker of non-alcoholic steatohepatitis in a Chinese population
Manuscript Source Unsolicited Manuscript
All Author List Xiao-Lin Liu, Qin Pan, Rui-Nan Zhang, Feng Shen, Shi-Yan Yan, Chao Sun, Zheng-Jie Xu, Yuan-Wen Chen and Jian-Gao Fan
Funding Agency and Grant Number
Funding Agency Grant Number
State Key Development Program for Basic Research of China 2012CB517501
National Natural Science Foundation of China 81270491
Hundred Talents Program of the Shanghai Board of Health XBR2011007
Program of the Shanghai Committee of Science and Technology 10411956300
National Natural Science Foundation of China 81470840
Corresponding author Jian-Gao Fan, Professor, Center for Fatty Liver, Department of Gastroenterology, Xin Hua Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, 1665 Kongjiang Road, Shanghai 200092, China. fattyliver2004@126.com
Keywords MicroRNA; Non-alcoholic steatohepatitis; Hepatic fibrosis; Biomarker; Chronic hepatitis B
Core Tip Circulating miR-122, -192, -34a and -16 showed differential expression levels between non-alcoholic fatty liver disease and chronic hepatitis B patients, and serum miR-122, -192 and -34a could also differentiate non-alcoholic steatohepatitis (NASH) from non-alcoholic fatty liver. The latter were correlated with steatosis and inflammatory activity, and only serum miR-16 was associated with hepatic fibrosis. The diagnostic value of miR-34a for NASH was superior to that of alanine aminotransferase and cytokeratin-18, but miR-16 showed a slightly poorer performance than that of fibrosis-4 and aspartate aminotransferase to platelet ratio index in the diagnosis of significant fibrosis in NASH.
Publish Date 2016-11-26 18:57
Citation Liu XL, Pan Q, Zhang RN, Shen F, Yan SY, Sun C, Xu ZJ, Chen YW, Fan JG. Disease-specific miR-34a as diagnostic marker of non-alcoholic steatohepatitis in a Chinese population. World J Gastroenterol 2016; 22(44): 9844-9852
Url http://www.wjgnet.com/1007-9327/full/v22/i44/9844.htm
DOI http://dx.doi.org/10.3748/wjg.v22.i44.9844
Full Article (PDF) WJG-22-9844.pdf
Full Article (Word) WJG-22-9844.doc
Manuscript File 28905-Review.docx
Answering Reviewers 28905-Answering reviewers.pdf
Audio Core Tip 28905-Audio core tip.mp3
Biostatistics Review Certificate Biostatistics_Statement_20160721151042.pdf
Conflict-of-Interest Disclosure Form 28905-Conflict-of-interest statement.pdf
Copyright License Agreement 28905-Copyright assignment.pdf
Approved Grant Application Form(s) or Funding Agency Copy of any Approval Document(s) 28905-Grant application form(s).pdf
Signed Informed Consent Form(s) or Document(s) Informed_Consent_Statement_20160721151046.pdf
Institutional Review Board Approval Form or Document 28905-Institutional review board statement.pdf
Non-Native Speakers of English Editing Certificate Editing_Certificate_20160721151114.pdf
Scientific Research Process 28905-Scientific research process.pdf
Peer-review Report 28905-Peer-review(s).pdf
Scientific Misconduct Check 28905-Scientific misconduct check.pdf
Scientific Editor Work List 28905-Scientific editor work list.pdf