| ISSN |
1007-9327 (print) and 2219-2840 (online) |
| Open Access |
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2016. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Gastroenterology & Hepatology |
| Manuscript Type |
Basic Study |
| Article Title |
Anticancer effect of linalool via cancer-specific hydroxyl radical generation in human colon cancer
|
| Manuscript Source |
Invited Manuscript |
| All Author List |
Kenichi Iwasaki, Yun-Wen Zheng, Soichiro Murata, Hiromu Ito, Ken Nakayama, Tomohiro Kurokawa, Naoki Sano, Takeshi Nowatari, Myra O Villareal, Yumiko N Nagano, Hiroko Isoda, Hirofumi Matsui and Nobuhiro Ohkohchi |
| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| Ministry of Education, Culture, Sports, Science, and Technology of Japan, KAKENHI |
25462069 (partly) |
| Ministry of Education, Culture, Sports, Science, and Technology of Japan, KAKENHI |
16K15604 (partly) |
| The Jiangsu innovative and entrepreneurial project for the introduction of high-level talent; The Jiangsu science and technology planning project |
BE2015669 |
| Novartis Pharma Research Foundation (to Zheng YW) |
|
| Japan Science and Technology Research Partnership for Sustainable Development (SATREPS) project FY2015 (to Isoda H) |
|
|
| Corresponding Author |
Yun-Wen Zheng, PhD, Associate Professor, Department of Surgery and Organ Transplantation, Faculty of Medicine, University of Tsukuba, Tsukuba-shi, Ibaraki 305-8575, Japan. ywzheng@md.tsukuba.ac.jp |
| Key Words |
Colorectal cancer; Linalool; Oxidative stress; Electron spin resonance; Lipid peroxidation |
| Core Tip |
We elucidated the anticancer mechanism of the monoterpenoid alcohol, linalool, which induces apoptosis specifically in cancer cells via lipid peroxidation. Electron spin resonance (ESR) spectroscopy, which enables the real-time visualization of free radicals in live cells, revealed that oxidative stress developed immediately after treatment only in cancer cells. This study demonstrated that the natural compound linalool exerted an anticancer effect without causing serious side effects, and that the further utilization of ESR may support the application of linalool as a new and cost-effective cancer therapy. |
| Publish Date |
2016-11-26 18:57 |
| Citation |
Iwasaki K, Zheng YW, Murata S, Ito H, Nakayama K, Kurokawa T, Sano N, Nowatari T, Villareal MO, Nagano YN, Isoda H, Matsui H, Ohkohchi N. Anticancer effect of linalool via cancer-specific hydroxyl radical generation in human colon cancer. World J Gastroenterol 2016; 22(44): 9765-9774 |
| URL |
http://www.wjgnet.com/1007-9327/full/v22/i44/9765.htm |
| DOI |
http://dx.doi.org/10.3748/wjg.v22.i44.9765 |
