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Articles Published Processes
12/13/2016 12:40:00 AM | Browse: 828 | Download: 1931
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Received |
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2016-07-22 09:58 |
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Peer-Review Started |
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2016-07-25 12:08 |
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To Make the First Decision |
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2016-09-20 10:51 |
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Return for Revision |
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2016-09-20 13:10 |
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Revised |
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2016-10-09 19:42 |
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Second Decision |
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2016-11-08 17:25 |
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Accepted by Journal Editor-in-Chief |
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2016-11-11 10:41 |
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Accepted by Executive Editor-in-Chief |
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2016-11-16 11:37 |
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Articles in Press |
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2016-11-16 11:37 |
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Publication Fee Transferred |
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Edit the Manuscript by Language Editor |
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Typeset the Manuscript |
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2016-12-02 14:14 |
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Publish the Manuscript Online |
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2016-12-13 00:40 |
| ISSN |
1007-9327 (print) and 2219-2840 (online) |
| Open Access |
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2016. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Microbiology |
| Manuscript Type |
Basic Study |
| Article Title |
NADPH oxidase-1 deficiency offers little protection in Salmonella typhimurium-induced typhlitis in mice
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| Manuscript Source |
Invited Manuscript |
| All Author List |
Fong-Fong Chu, R Steven Esworthy, James H Doroshow and Binghui Shen |
| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| Federal funds from the National Cancer Institute (NCI) under Contract |
No. HHSN261200800001E (to Chu FF) |
| National Cancer Institute of the National Institutes of Health |
P30CA033572 |
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| Corresponding Author |
Fong-Fong Chu, PhD, Staff Scientist, Department of Cancer Genetics and Epigenetics, Beckman Research Institute of City of Hope, 1450 E Duarte Road, Duarte, CA 91010, United States. fchu@coh.org |
| Key Words |
Knockout mouse; NADPH Oxidase-1; Salmonella typhimurium; Goblet cells; Reactive oxygen species |
| Core Tip |
Using Nox1-knockout mice (Nox1-KO), we examined the role of cecum Nox1 in Salmonella typhimurium (S. Tm) infection. Mice were rendered susceptible to infection with oral metronidazole. Four days after S. Tm inoculation, Nox1-KO mice had equal or slightly lower CFU/g cecum contents and equal or slightly less pathology by histological assessment than wild-type (WT) mice. Quantitative real-time PCR measure of mRNA levels for inflammatory cytokines Il-1β and TNF-α were significantly higher in S. Tm treated WT vs untreated mice but not in S. Tm treated Nox1-KO mice. Since Nox1 may have a role in inflammatory bowel disease, treating subjects with Nox1 inhibitors may not make patients vulnerable to pathogens. |
| Publish Date |
2016-12-13 00:40 |
| Citation |
Chu FF, Esworthy RS, Doroshow JH, Shen B. NADPH oxidase-1 deficiency offers little protection in Salmonella typhimurium-induced typhlitis in mice. World J Gastroenterol 2016; 22(46): 10158-10165 |
| URL |
http://www.wjgnet.com/1007-9327/full/v22/i46/10158.htm |
| DOI |
http://dx.doi.org/10.3748/wjg.v22.i46.10158 |
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