Publication Name	World Journal of Gastroenterology
Manuscript ID	29000
Country	San Marino

Received	2016-07-25 09:53
Peer-Review Started	2016-07-26 11:20
To Make the First Decision	2016-09-20 10:51
Return for Revision	2016-09-20 13:20
Revised	2016-10-25 05:45
Second Decision	2016-11-11 16:45
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief	2016-11-16 13:23
Articles in Press	2016-11-16 13:30
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2016-12-02 14:13
Publish the Manuscript Online	2016-12-13 00:40

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access	This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright	© The Author(s) 2016. Published by Baishideng Publishing Group Inc. All rights reserved.
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Website	http://www.wjgnet.com

Category	Gastroenterology & Hepatology
Manuscript Type	Case Control Study
Article Title	Nodular lymphoid hyperplasia: A marker of low-grade inflammation in irritable bowel syndrome?
Manuscript Source	Invited Manuscript
All Author List	Anna Chiara Piscaglia, Lucrezia Laterza, Valentina Cesario, Viviana Gerardi, Rosario Landi, Loris Riccardo Lopetuso, Giovanni Calò, Giovanna Fabbretti, Massimo Brisigotti, Maria Loredana Stefanelli and Antonio Gasbarrini
Funding Agency and Grant Number
Corresponding Author	Anna Chiara Piscaglia, MD, PhD, Endoscopy and Gastroenterology Unit, Depatment of Internal Medicine, State Hospital, Via Scialoja, 47893 Borgo Maggiore, Republic of San Marino. annachiarapiscaglia@hotmail.com
Key Words	Inflammatory bowel diseases; Functional gastrointestinal diseases; Irritable bowel syndrome; Colonoscopy; Inflammation
Core Tip	This study sheds light on colonic nodular lymphoid hyperplasia (NLH) in terms of prevalence, gender-distribution and association with known diseases. Our most relevant result is the identification of NLH as a putative marker of low-grade inflammation in a conspicuous subset of irritable bowel syndrome (IBS) cases. Further studies are required to understand the etiopathogenetic mechanisms underlying NLH in IBS, its association with metal contact allergies and its clinical implications.
Publish Date	2016-12-13 00:40
Citation	Piscaglia AC, Laterza L, Cesario V, Gerardi V, Landi R, Lopetuso LR, Calò G, Fabbretti G, Brisigotti M, Stefanelli ML, Gasbarrini A. Nodular lymphoid hyperplasia: A marker of low-grade inflammation in irritable bowel syndrome? World J Gastroenterol 2016; 22(46): 10198-10209
URL	http://www.wjgnet.com/1007-9327/full/v22/i46/10198.htm
DOI	http://dx.doi.org/10.3748/wjg.v22.i46.10198

Full Article (PDF)	WJG-22-10198.pdf
Full Article (Word)	WJG-22-10198.doc
Manuscript File	29000-Review.docx
Answering Reviewers	29000-Answering reviewers.pdf
Audio Core Tip	29000-Audio core tip.mp3
Biostatistics Review Certificate	29000-Biostatistics statement.pdf
Conflict-of-Interest Disclosure Form	Conflict-of-Interest_Statement_20160724153808.pdf
Copyright License Agreement	29000-Copyright assignment.pdf
Institutional Review Board Approval Form or Document	Institutional_Review_Board_Statement_20160724151850.pdf
Peer-review Report	29000-Peer-review(s).pdf
Scientific Misconduct Check	29000-Scientific misconduct check.pdf
Scientific Editor Work List	29000-Scientific editor work list.pdf