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Articles Published Processes
12/26/2016 7:12:00 PM | Browse: 814 | Download: 1777
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Received |
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2016-07-28 09:43 |
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Peer-Review Started |
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2016-07-30 19:18 |
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To Make the First Decision |
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2016-08-29 08:32 |
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Return for Revision |
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2016-08-31 09:44 |
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Revised |
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2016-09-17 06:28 |
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Second Decision |
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2016-09-30 10:51 |
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Accepted by Journal Editor-in-Chief |
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Accepted by Company Editor-in-Chief |
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2016-10-10 17:17 |
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Articles in Press |
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2016-10-10 17:17 |
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Publication Fee Transferred |
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Edit the Manuscript by Language Editor |
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Typeset the Manuscript |
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2016-12-18 18:32 |
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Publish the Manuscript Online |
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2016-12-26 19:13 |
| ISSN |
1007-9327 (print) and 2219-2840 (online) |
| Open Access |
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2016. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Gastroenterology & Hepatology |
| Manuscript Type |
Basic Study |
| Article Title |
Effects of asymmetric dimethylarginine on renal arteries in portal hypertension and cirrhosis
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| Manuscript Source |
Invited Manuscript |
| All Author List |
Gloria Segarra, Belén Cortina, María Dolores Mauricio, Susana Novella, Paloma Lluch, Javier Navarrete-Navarro, Inmaculada Noguera and Pascual Medina |
| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| Consellería de Sanidad of the Generalitat Valenciana |
AP-052/08 |
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| Corresponding Author |
Pascual Medina, PhD, Department of Physiology, University of Valencia and Institute of Health Research INCLIVA, Hospital Clínico Universitario Valencia, Avenida Blasco Ibáñez 15, 46010 Valencia, Spain. pascual.medina@uv.es |
| Key Words |
Portal hypertension; Cirrhosis; Nitric oxide; Asymmetric dimethylarginine; Nitric oxide inhibitors; Dimethylarginine dimethylaminohydrolase |
| Core Tip |
Cirrhosis is associated with renal dysfunction and renal vasoconstriction. This constriction leads to decreased renal blood flow and glomerular filtration. Decreased nitric oxide (NO) bioavailability is involved in these effects. Although plasma levels of asymmetric dimethylarginine (ADMA), an endogenous inhibitor of NO synthase, are increased in cirrhosis, the effects of ADMA on renal arteries under this pathological condition are unknown. Therefore, the present work studied the effects of ADMA on basal- and stimulated-NO release in renal arteries from portal hypertensive and cirrhotic rats and the renal expression and activity of dimethylarginine dimethylaminohydrolase, an enzyme that catabolizes ADMA. |
| Publish Date |
2016-12-26 19:13 |
| Citation |
Segarra G, Cortina B, Mauricio MD, Novella S, Lluch P, Navarrete-Navarro J, Noguera I, Medina P. Effects of asymmetric dimethylarginine on renal arteries in portal hypertension and cirrhosis. World J Gastroenterol 2016; 22(48): 10545-10556 |
| URL |
http://www.wjgnet.com/1007-9327/full/v22/i48/10545.htm |
| DOI |
http://dx.doi.org/10.3748/wjg.v22.i48.10545 |
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