Publication Name	World Journal of Gastroenterology
Manuscript ID	29064
Country	Japan

Received	2016-07-27 14:15
Peer-Review Started	2016-08-01 17:15
First Decision by Editorial Office Director
Return for Revision	2016-08-24 19:01
Revised	2016-10-18 13:17
Publication Fee Transferred
Second Decision by Editor	2016-11-07 09:21
Second Decision by Editor-in-Chief	2016-11-10 03:26
Final Decision by Editorial Office Director	2016-11-13 15:29
Articles in Press	2016-11-13 15:30
Edit the Manuscript by Language Editor
Typeset the Manuscript	2016-12-07 15:01
Publish the Manuscript Online	2016-12-19 20:29

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access	This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright	© The Author(s) 2016. Published by Baishideng Publishing Group Inc. All rights reserved.
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Website	http://www.wjgnet.com

Category	Gastroenterology & Hepatology
Manuscript Type	Observational Study
Article Title	Relationship between ghrelin, Helicobacter pylori and gastric mucosal atrophy in hemodialysis patients
Manuscript Source	Invited Manuscript
All Author List	Hitomi Ichikawa, Mitsushige Sugimoto, Yukitoshi Sakao, Shu Sahara, Naro Ohashi, Akihiko Kato, Ken Sugimoto, Takahisa Furuta, Akira Andoh, Tadashi Sakao and Hideo Yasuda
Funding Agency and Grant Number	Funding Agency Grant Number Japanese Association of Dialysis Physicians 2014-2
Corresponding Author	Mitsushige Sugimoto, MD, PhD, Division of Digestive Endoscopy, Shiga University of Medical Science Hospital, Seta Tsukinowa-cho, Otsu, Shiga 520-2192, Japan. sugimo@belle.shiga-med.ac.jp
Key Words	Acyl-ghrelin; Desacyl-ghrelin; Helicobacter pylori; Hemodialysis; Pepsinogen
Core Tip	Ghrelin enhances the orexigenic effect, protein anabolism, anti-inflammatory actions and cardiovascular protection in hemodialysis patients. Helicobacter pylori (H. pylori) infection and gastric mucosal atrophy affect ghrelin level in subjects with normal renal function. However, it is unclear whether ghrelin in hemodialysis patients relates to H. pylori status or gastric mucosal atrophy. This study demonstrated that plasma ghrelin level was associated with endoscopic and serological severity of atrophy related with H. pylori infection in hemodalysis patients. Therefore, eradication therapy of H. pylori before the progression of atrophy might improve ghrelin level associated with nutrition status, such as protein-energy wasting.
Publish Date	2016-12-19 20:29
Citation	Ichikawa H, Sugimoto M, Sakao Y, Sahara S, Ohashi N, Kato A, Sugimoto K, Furuta T, Andoh A, Sakao T, Yasuda H. Relationship between ghrelin, Helicobacter pylori and gastric mucosal atrophy in hemodialysis patients. World J Gastroenterol 2016; 22(47): 10440-10449
URL	http://www.wjgnet.com/1007-9327/full/v22/i47/10440.htm
DOI	http://dx.doi.org/10.3748/wjg.v22.i47.10440

Full Article (PDF)	WJG-22-10440.pdf
Full Article (Word)	WJG-22-10440.doc
Manuscript File	29064-Review.docx
Answering Reviewers	29064-Answering reviewers.pdf
Audio Core Tip	29064-Audio core tip.mp3
Biostatistics Review Certificate	29064-Biostatistics statement.pdf
Conflict-of-Interest Disclosure Form	29064-Conflict-of-interest statement.pdf
Copyright License Agreement	29064-Copyright assignment.pdf
Institutional Review Board Approval Form or Document	29064-Institutional review board statement.pdf
Non-Native Speakers of English Editing Certificate	29064-Language certificate.pdf
Peer-review Report	29064-Peer-review(s).pdf
Journal Editor-in-Chief Review Report	29064-Journal editor-in-chief review report.pdf
Scientific Misconduct Check	29064-Scientific misconduct check.pdf
Scientific Editor Work List	29064-Scientific editor work list.pdf