Publication Name	World Journal of Gastroenterology
Manuscript ID	29526
Country	China

Received	2016-08-19 11:34
Peer-Review Started	2016-08-19 17:15
To Make the First Decision	2016-09-06 16:38
Return for Revision	2016-09-07 08:30
Revised	2016-09-20 16:05
Second Decision	2016-10-14 18:08
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2016-10-19 17:33
Articles in Press	2016-10-19 17:33
Publication Fee Transferred
Edit the Manuscript by Language Editor	2016-10-24 11:21
Typeset the Manuscript	2016-10-31 09:25
Publish the Manuscript Online	2016-11-06 15:43

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access	This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright	© The Author(s) 2016. Published by Baishideng Publishing Group Inc. All rights reserved.
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Category	Pathology
Manuscript Type	Review
Article Title	Genetic alterations in hepatocellular carcinoma: An update
Manuscript Source	Invited Manuscript
All Author List	Zhao-Shan Niu, Xiao-Jun Niu and Wen-Hong Wang
Funding Agency and Grant Number
Corresponding Author	Zhao-Shan Niu, MD, Laboratory of Micromorphology, School of Basic Medicine, Medical Department of Qingdao University, Room 201, Building Boya, 308 Ningxia Road, Qingdao 266071, Shandong Province, China. niumiao1993@hotmail.com
Key Words	Genetic alterations; Chromosomal instability; Somatic mutations; Signaling pathways; Hepatocellular carcinoma
Core Tip	Hepatocellular carcinoma (HCC) is one of the leading causes of cancer-related deaths worldwide. The poor survival rate is mainly due to late diagnosis of HCC. Elucidating the molecular mechanisms underlying hepatocarcinogenesis is critical for making early diagnoses of and developing targeted therapies for HCC. Recent studies on HCC using deep sequencing have provided increasing lines of evidence indicating that genetic alterations play important roles in the initiation and progression of HCC, which are summarized in this article. We also attempt to elucidate some of the genetic mechanisms underlying HCC, which may help in making early diagnoses of and developing molecularly targeted therapies for this disease.
Publish Date	2016-11-06 15:43
Citation	Niu ZS, Niu XJ, Wang WH. Genetic alterations in hepatocellular carcinoma: An update. World J Gastroenterol 2016; 22(41): 9069-9095
URL	http://www.wjgnet.com/1007-9327/full/v22/i41/9069.htm
DOI	http://dx.doi.org/10.3748/wjg.v22.i41.9069

Full Article (PDF)	WJG-22-9069.pdf
Full Article (Word)	WJG-22-9069.doc
Manuscript File	29526-Review.docx
Answering Reviewers	29526-Answering reviewers.pdf
Audio Core Tip	29526-Audio core tip.mp3
Conflict-of-Interest Disclosure Form	29526-Conflict-of-interest statement.pdf
Copyright License Agreement	29526-Copyright assignment.pdf
Non-Native Speakers of English Editing Certificate	29526-Language certificate.pdf
Peer-review Report	29526-Peer-review(s).pdf
Scientific Misconduct Check	29526-Scientific misconduct check.pdf
Scientific Editor Work List	29526-Scientific editor work list.pdf