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Articles Published Processes
11/26/2016 6:56:00 PM | Browse: 1057 | Download: 2055
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Received |
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2016-08-22 10:24 |
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Peer-Review Started |
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2016-08-24 14:37 |
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To Make the First Decision |
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2016-09-05 14:18 |
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Return for Revision |
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2016-09-07 11:19 |
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Revised |
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2016-09-20 17:59 |
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Second Decision |
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2016-09-22 17:06 |
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Accepted by Journal Editor-in-Chief |
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Accepted by Executive Editor-in-Chief |
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2016-09-28 18:59 |
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Articles in Press |
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2016-09-28 18:59 |
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Publication Fee Transferred |
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Edit the Manuscript by Language Editor |
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Typeset the Manuscript |
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2016-11-17 16:17 |
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Publish the Manuscript Online |
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2016-11-26 18:57 |
| ISSN |
1007-9327 (print) and 2219-2840 (online) |
| Open Access |
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2016. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Oncology |
| Manuscript Type |
Retrospective Study |
| Article Title |
Prognostic implications of FGFR1 and MYC status in esophageal squamous cell carcinoma
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| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Dohee Kwon, Ji Yun Yun, Bhumsuk Keam, Young Tae Kim and Yoon Kyung Jeon |
| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| National Research Foundation for the Global Core Research Center |
2016005276 |
| Korea Health Technology R&D Project through the Korea Health Industry Development Institute |
HI14C0069 |
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| Corresponding Author |
Yoon Kyung Jeon, MD, PhD, Department of Pathology, Seoul National University Hospital, 101 Daehak-ro, Jongno-gu, Seoul 03080, South Korea. junarplus@chol.com |
| Key Words |
Receptor tyrosine kinase; Fibroblast growth factor receptor 1; MYC; Esophageal squamous cell carcinoma; Gene amplification; Prognosis; Fluorescent in situ hybridization |
| Core Tip |
MYC expression, together with fibroblast growth factor receptor 1 (FGFR1) amplification, was reported to modulate oncogenic transformation. We evaluated both FGFR1 and MYC statuses in patients with resected esophageal squamous cell carcinoma (ESCC). FGFR1 and MYC amplifications were observed in 21.4% and 54.2% of patients with ESCC, respectively, while 12.3% exhibited both FGFR1 amplification and MYC expression. MYC expression and FGFR1 amplification were significantly associated with prolonged survival. Combined FGFR1 amplification and MYC expression was a predictor of better survival in patients who did not receive adjuvant therapy, but not in those who did. As such, FGFR1 and MYC might have prognostic implications in resected ESCCs with respect to adjuvant therapy. |
| Publish Date |
2016-11-26 18:57 |
| Citation |
Kwon D, Yun JY, Keam B, Kim YT, Jeon YK. Prognostic implications of FGFR1 and MYC status in esophageal squamous cell carcinoma. World J Gastroenterol 2016; 22(44): 9803-9812 |
| URL |
http://www.wjgnet.com/1007-9327/full/v22/i44/9803.htm |
| DOI |
http://dx.doi.org/10.3748/wjg.v22.i44.9803 |
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