Publication Name	World Journal of Gastroenterology
Manuscript ID	29661
Country	China

Received	2016-08-24 08:41
Peer-Review Started	2016-08-24 20:39
First Decision by Editorial Office Director
Return for Revision	2016-09-29 14:49
Revised	2016-10-10 22:09
Publication Fee Transferred
Second Decision by Editor	2016-11-11 14:33
Second Decision by Editor-in-Chief	2016-11-14 00:49
Final Decision by Editorial Office Director	2016-11-16 16:27
Articles in Press	2016-11-16 16:27
Edit the Manuscript by Language Editor
Typeset the Manuscript	2016-12-20 19:42
Publish the Manuscript Online	2016-12-26 19:13

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access	This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright	© The Author(s) 2016. Published by Baishideng Publishing Group Inc. All rights reserved.
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Category	Gastroenterology & Hepatology
Manuscript Type	Basic Study
Article Title	Regulating effect of TongXie-YaoFang on colonic epithelial secretion via Cl- and HCO3- channel
Manuscript Source	Unsolicited Manuscript
All Author List	Cheng Yang, Ying Xiong, Sheng-Sheng Zhang, Fang-Mei An, Jing Sun, Qing-Lin Zhang and Qiang Zhan
Funding Agency and Grant Number	Funding Agency Grant Number Medical and public health technology research and development projects of WuXi science and technology development fund CSE31N1501
Corresponding Author	Zhan Qiang, PhD, Associate Professor, Department of Gastroenterology, Wuxi People’s Hospital, Nanjing Medical University, 299 Qing-Yang Road, Nan-Chang District, Wuxi 214023, Jiangsu Province, China. zhanq33@163.com
Key Words	Ion channel; Diarrhea-predominant irritable bowel syndrome; Colonic mucosa; Short-circuit current; TongXie-YaoFang formula
Core Tip	Diarrhea-predominant irritable bowel syndrome (D-IBS) is a chronic functional gastrointestinal disease. Abnormal ion secretion of colonic mucosal epithelial cells is recognized as one of the pathophysiological factors. In this paper, through the observation of TongXie-YaoFang (TXYF) formula, a Chinese herbal formula, to D-IBS rats obtained by neonatal maternal separation plus restraint stress. The mucosal stripping under a microscope was used for tissue preparation. Short-circuit current technology was used for testing 5-HT-induced changes in the current across ion channels of colonic epithelium. The results indicated that TXYF-formula could regulate the secretion of Cl- and HCO3- in colonic mucosa via cystic fibrosis transmembrane conductance regulator (CFTR) Cl- channel, Cl-/HCO3- exchanger, Na+-HCO3- co-transporter and Na+-K+-2Cl- co-transporter co-transporters.
Publish Date	2016-12-26 19:13
Citation	Yang C, Xiong Y, Zhang SS, An FM, Sun J, Zhang QL, Zhan Q. Regulating effect of TongXie-YaoFang on colonic epithelial secretion via Cl- and HCO3- channel. World J Gastroenterol 2016; 22(48): 10584-10591
URL	http://www.wjgnet.com/1007-9327/full/v22/i48/10584.htm
DOI	http://dx.doi.org/10.3748/wjg.v22.i48.10584

Full Article (PDF)	WJG-22-10584.pdf
Full Article (Word)	WJG-22-10584.doc
Manuscript File	29661-Review.docx
Answering Reviewers	29661-Answering reviewers.pdf
Audio Core Tip	29661-Audio core tip.mp3
Biostatistics Review Certificate	29661-Biostatistics statement.pdf
Conflict-of-Interest Disclosure Form	29661-Conflict-of-interest statement.pdf
Copyright License Agreement	29661-Copyright assignment.pdf
Institutional Animal Care and Use Committee Approval Form or Document	29661-Institutional animal care and use committee statement.pdf
Institutional Review Board Approval Form or Document	29661-Institutional review board statement.pdf
Non-Native Speakers of English Editing Certificate	29661-Language certificate.pdf
Peer-review Report	29661-Peer-review(s).pdf
Journal Editor-in-Chief Review Report	29661-Journal editor-in-chief review report.pdf
Scientific Misconduct Check	29661-Scientific misconduct check.pdf
Scientific Editor Work List	29661-Scientific editor work list.pdf