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Publication Name World Journal of Gastroenterology
Manuscript ID 29696
Country/Territory Italy
2016-08-25 09:34
Peer-Review Started
2016-08-27 14:25
To Make the First Decision
2016-09-20 08:35
Return for Revision
2016-11-03 17:14
2016-10-07 04:12
Second Decision
2017-01-16 11:00
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief
2017-01-18 16:16
Articles in Press
2017-01-18 16:16
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript
2017-02-08 17:41
Publish the Manuscript Online
2017-02-26 18:20
ISSN 1007-9327 (print) and 2219-2840 (online)
Open Access This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright © The Author(s) 2017. Published by Baishideng Publishing Group Inc. All rights reserved.
Article Reprints For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
Permissions For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website http://www.wjgnet.com
Category Gastroenterology and Hepatology
Manuscript Type Observational Study
Article Title Clinical features and natural history of cryptogenic cirrhosis compared to hepatitis C virus-related cirrhosis
Manuscript Source Invited Manuscript
All Author List Luca Rinaldi, Fabio Nascimbeni, Mauro Giordano, Chiara Masetti, Barbara Guerrera, Annalisa Amelia, Maria Chiara Fascione, Stefano Ballestri, Dante Romagnoli, Rosa Zampino, Riccardo Nevola, Enrica Baldelli, Natalina Iuliano, Valerio Rosato, Amedeo Lonardo and Luigi Elio Adinolfi
Funding Agency and Grant Number
Corresponding author Dr. Luigi Elio Adinolfi, Professor, Department of Medical, Surgical, Neurological, Metabolic, and Geriatric Sciences, Second University of Naples, Piazza Miraglia, 80100 Napoli, Italy. luigielio.adinolfi@unina2.it
Keywords Liver cirrhosis; Hepatocellular carcinoma; Metabolic syndrome; Nonalcoholic fatty liver disease; Cardiovascular diseases
Core Tip We evaluated the features and outcomes of cryptogenic cirrhosis (CC) compared to age- and Child-Pugh class-matched hepatitis C virus-related cirrhosis at baseline and over a 42-mo follow-up. At diagnosis, the median age of CC was 66 years and Child-Pugh classes A/B/C were 47%/31%/22%, respectively. Among CC cases higher prevalences of metabolic syndrome, overweight/obesity, high BMI, impaired glucose metabolism, high blood pressure, dyslipidemia, hyperuricemia, cardiovascular diseases, extrahepatic cancer, and gallstones were observed. Although in the two groups we detected a similar incidence of liver decompensation, hepatocellular carcinoma (HCC) and death, an earlier development of HCC was observed in CC. Age and Child-Pugh were predictors of death. Most CC cases are the consequence of undiagnosed nonalcoholic fatty liver disease.
Publish Date 2017-02-26 18:20
Citation Rinaldi L, Nascimbeni F, Giordano M, Masetti C, Guerrera B, Amelia A, Fascione MC, Ballestri S, Romagnoli D, Zampino R, Nevola R, Baldelli E, Iuliano N, Rosato V, Lonardo A, Adinolfi LE. Clinical features and natural history of cryptogenic cirrhosis compared to hepatitis C virus-related cirrhosis. World J Gastroenterol 2017; 23(8): 1458-1468
Url http://www.wjgnet.com/1007-9327/full/v23/i8/1458.htm
DOI http://dx.doi.org/10.3748/wjg.v23.i8.1458
Full Article (PDF) WJG-23-1458.pdf
Full Article (Word) WJG-23-1458.doc
Manuscript File 29696-Review.docx
Answering Reviewers 29696-Answering reviewers.pdf
Audio Core Tip 29696-Audio core tip.m4a
Biostatistics Review Certificate 29696-Biostatistics statement.pdf
Conflict-of-Interest Disclosure Form 29696-Conflict-of-interest statement.pdf
Copyright License Agreement 29696-Copyright assignment.pdf
Data Sharing Statement 29696-Data sharing statement.pdf
Institutional Review Board Approval Form or Document 29696-Institutional review board statement.pdf
Non-Native Speakers of English Editing Certificate 29696-Language certificate.pdf
Scientific Research Process 29696-Scientific research process.pdf
Peer-review Report 29696-Peer-review(s).pdf
Scientific Misconduct Check 29696-Scientific misconduct check.pdf
Scientific Editor Work List 29696-Scientific editor work list.pdf