ISSN |
1007-9327 (print) and 2219-2840 (online) |
Open Access |
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/ |
Copyright |
© The Author(s) 2017. Published by Baishideng Publishing Group Inc. All rights reserved. |
Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
|
Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
|
Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
Website |
http://www.wjgnet.com |
Category |
Gastroenterology & Hepatology |
Manuscript Type |
Observational Study |
Article Title |
Clinical features and natural history of cryptogenic cirrhosis compared to hepatitis C virus-related cirrhosis
|
Manuscript Source |
Invited Manuscript |
All Author List |
Luca Rinaldi, Fabio Nascimbeni, Mauro Giordano, Chiara Masetti, Barbara Guerrera, Annalisa Amelia, Maria Chiara Fascione, Stefano Ballestri, Dante Romagnoli, Rosa Zampino, Riccardo Nevola, Enrica Baldelli, Natalina Iuliano, Valerio Rosato, Amedeo Lonardo and Luigi Elio Adinolfi |
Funding Agency and Grant Number |
|
Corresponding Author |
Dr. Luigi Elio Adinolfi, Professor, Department of Medical, Surgical, Neurological, Metabolic, and Geriatric Sciences, Second University of Naples, Piazza Miraglia, 80100 Napoli, Italy. luigielio.adinolfi@unina2.it |
Key Words |
Liver cirrhosis; Hepatocellular carcinoma; Metabolic syndrome; Nonalcoholic fatty liver disease; Cardiovascular diseases |
Core Tip |
We evaluated the features and outcomes of cryptogenic cirrhosis (CC) compared to age- and Child-Pugh class-matched hepatitis C virus-related cirrhosis at baseline and over a 42-mo follow-up. At diagnosis, the median age of CC was 66 years and Child-Pugh classes A/B/C were 47%/31%/22%, respectively. Among CC cases higher prevalences of metabolic syndrome, overweight/obesity, high BMI, impaired glucose metabolism, high blood pressure, dyslipidemia, hyperuricemia, cardiovascular diseases, extrahepatic cancer, and gallstones were observed. Although in the two groups we detected a similar incidence of liver decompensation, hepatocellular carcinoma (HCC) and death, an earlier development of HCC was observed in CC. Age and Child-Pugh were predictors of death. Most CC cases are the consequence of undiagnosed nonalcoholic fatty liver disease. |
Publish Date |
2017-02-26 18:20 |
Citation |
Rinaldi L, Nascimbeni F, Giordano M, Masetti C, Guerrera B, Amelia A, Fascione MC, Ballestri S, Romagnoli D, Zampino R, Nevola R, Baldelli E, Iuliano N, Rosato V, Lonardo A, Adinolfi LE. Clinical features and natural history of cryptogenic cirrhosis compared to hepatitis C virus-related cirrhosis. World J Gastroenterol 2017; 23(8): 1458-1468 |
URL |
http://www.wjgnet.com/1007-9327/full/v23/i8/1458.htm |
DOI |
http://dx.doi.org/10.3748/wjg.v23.i8.1458 |