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Articles Published Processes
5/16/2017 6:56:36 AM | Browse: 1426 | Download: 2308
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Received |
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2016-08-29 15:31 |
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Peer-Review Started |
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2016-09-01 16:45 |
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To Make the First Decision |
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2016-10-31 08:19 |
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Return for Revision |
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2016-11-03 18:09 |
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Revised |
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2016-12-01 09:03 |
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Second Decision |
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2017-02-15 18:52 |
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Accepted by Journal Editor-in-Chief |
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Accepted by Executive Editor-in-Chief |
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2017-03-02 08:16 |
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Articles in Press |
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2017-03-02 08:16 |
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Publication Fee Transferred |
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Edit the Manuscript by Language Editor |
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Typeset the Manuscript |
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2017-05-13 18:00 |
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Publish the Manuscript Online |
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2017-05-16 06:56 |
| ISSN |
2150-5330 (online) |
| Open Access |
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2017. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Gastroenterology & Hepatology |
| Manuscript Type |
Basic Study |
| Article Title |
Combination curcumin and vitamin E treatment attenuates diet-induced steatosis in Hfe-/- mice
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| Manuscript Source |
Invited Manuscript |
| All Author List |
Mandy Heritage, Lesley Jaskowski, Kim Bridle, Catherine Campbell, David Briskey, Laurence Britton, Linda Fletcher, Luis Vitetta, V Nathan Subramaniam and Darrell Crawford |
| Funding Agency and Grant Number |
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| Corresponding Author |
Dr. Kim Bridle, School of Medicine, The University of Queensland, Lower Lobby Level, Administration Building, Greenslopes Private Hospital, Newdegate Street, Brisbane 4120, Australia. k.bridle@uq.edu.au |
| Key Words |
Non-alcoholic fatty liver disease; hemochromatosis; iron overload; steatosis; high calorie diet |
| Core Tip |
The high prevalence of obesity and the metabolic syndrome suggests that many patients with liver disease of varying etiologies will have co-existent non-alcoholic fatty liver disease. Our model of co-toxic liver disease incorporates increased hepatic iron in combination with steatosis and was associated with necroinflammation and early hepatic fibrosis. Because of the beneficial effect of combination therapy, we believe vitamin E and curcumin should be investigated in other animal models of non-alcoholic steatohepatitis. Should beneficial effects be demonstrated, combination treatment with the development of appropriate dosing strategies could be rapidly moved to human studies allowing for an effective treatment strategy. |
| Publish Date |
2017-05-16 06:56 |
| Citation |
Heritage M, Jaskowski L, Bridle K, Campbell C, Briskey D, Britton L, Fletcher L, Vitetta L, Subramaniam VN, Crawford D. Combination curcumin and vitamin E treatment attenuates diet-induced steatosis in Hfe-/- mice. World J Gastrointest Pathophysiol 2017; 8(2): 67-76 |
| URL |
http://www.wjgnet.com/2150-5330/full/v8/i2/67.htm |
| DOI |
http://dx.doi.org/10.4291/wjgp.v8.i2.67 |
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