Publication Name	World Journal of Gastroenterology
Manuscript ID	30037
Country	China

Received	2016-09-06 08:42
Peer-Review Started	2016-09-06 18:14
To Make the First Decision	2016-09-28 09:24
Return for Revision	2016-09-28 14:56
Revised	2016-10-09 20:34
Second Decision	2016-11-08 17:28
Accepted by Journal Editor-in-Chief	2016-11-08 23:14
Accepted by Executive Editor-in-Chief	2016-11-16 11:42
Articles in Press	2016-11-16 11:42
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2016-12-28 11:48
Publish the Manuscript Online	2017-01-05 11:10

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access	This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright	© The Author(s) 2017. Published by Baishideng Publishing Group Inc. All rights reserved.
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Category	Gastroenterology & Hepatology
Manuscript Type	Basic Study
Article Title	miRNA-133a-UCP2 pathway regulates inflammatory bowel disease progress by influencing inflammation, oxidative stress and energy metabolism
Manuscript Source	Invited Manuscript
All Author List	Xi Jin, Dong Chen, Ruo-Heng Zheng, Hong Zhang, Yi-Peng Chen and Zun Xiang
Funding Agency and Grant Number	Funding Agency Grant Number National Natural Science Foundation of China 81370008 National Natural Science Foundation of China 81000169 Natural Science Foundation of Zhejiang Province R2110159 Natural Science Foundation of Zhejiang Province LY15H030006 Natural Science Foundation of Zhejiang Province LY16H030003
Corresponding Author	Zun Xiang, PhD, Department of Gastro­enterology, The First Affiliated Hospital, School of Medicine, Zhejiang University, No. 79 Qingchun Road, Hangzhou 310003, Zhejiang Province, China. jxfl007@zju.edu.cn
Key Words	miR-133a; Mitochondrial uncoupling protein 2; Inflammatory bowel disease; Dextran sulfate sodium
Core Tip	The pathogenesis of inflammatory bowel disease (IBD) is unclear, but increasing evidence supports the involvement of epigenetic regulation such as the formation of miRNA-mRNA pairs. In this study, we investigated the role of the miR-133a-UCP2 pathway in the pathogenesis of IBD in a well-established mouse model. We found that the severity of IBD was alleviated after the UCP2 and miR-133a levels were antagonized and that the underlying mechanism may involve changes in inflammation, oxidative stress and energy metabolism. Our data provide novel clues and potential therapeutic targets for IBD.
Publish Date	2017-01-05 11:10
Citation	Jin X, Chen D, Zheng RH, Zhang H, Chen YP, Xiang Z. miRNA-133a-UCP2 pathway regulates inflammatory bowel disease progress by influencing inflammation, oxidative stress and energy metabolism. World J Gastroenterol 2017; 23(1): 76-86
URL	http://www.wjgnet.com/1007-9327/full/v23/i1/76.htm
DOI	http://dx.doi.org/10.3748/wjg.v23.i1.76

Full Article (PDF)	WJG-23-76.pdf
Full Article (Word)	WJG-23-76.doc
Manuscript File	30037-Review.docx
Answering Reviewers	30037-Answering reviewers.pdf
Audio Core Tip	30037-Audio core tip.wma
Biostatistics Review Certificate	30037-Biostatistics statement.pdf
Conflict-of-Interest Disclosure Form	30037-Conflict-of-interest statement.pdf
Copyright License Agreement	30037-Copyright assignment.pdf
Approved Grant Application Form(s) or Funding Agency Copy of any Approval Document(s)	30037-Grant application form(s).pdf
Institutional Animal Care and Use Committee Approval Form or Document	30037-Institutional animal care and use committee statement.pdf
Institutional Review Board Approval Form or Document	30037-Institutional review board statement.pdf
Non-Native Speakers of English Editing Certificate	30037-Language certificate.pdf
Supplementary Material	Supplementary_Material_20160905182753.pdf
Peer-review Report	30037-Peer-review(s).pdf
Journal Editor-in-Chief Review Report	30037-Journal editor-in-chief review report.pdf
Scientific Misconduct Check	30037-Scientific misconduct check.pdf
Scientific Editor Work List	30037-Scientific editor work list.pdf