Publication Name	World Journal of Gastrointestinal Pharmacology and Therapeutics
Manuscript ID	30070
Country	Portugal

Received	2016-09-08 11:04
Peer-Review Started
First Decision by Editorial Office Director
Return for Revision	2016-09-09 16:42
Revised	2016-10-11 20:37
Publication Fee Transferred
Second Decision by Editor	2016-11-03 13:53
Second Decision by Editor-in-Chief	2016-11-04 01:44
Final Decision by Editorial Office Director	2016-11-17 15:12
Articles in Press	2016-11-17 15:12
Edit the Manuscript by Language Editor
Typeset the Manuscript	2017-01-12 17:33
Publish the Manuscript Online	2017-01-20 16:40

ISSN	2150-5349 (online)
Open Access	This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright	© The Author(s) 2017. Published by Baishideng Publishing Group Inc. All rights reserved.
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Website	http://www.wjgnet.com

Category	Psychiatry
Manuscript Type	Review
Article Title	Psychotropic drugs and liver disease: A critical review of pharmacokinetics and liver toxicity
Manuscript Source	Invited Manuscript
All Author List	Diogo Telles-Correia, António Barbosa, Helena Cortez-Pinto, Carlos Campos, Nuno B F Rocha and Sérgio Machado
Funding Agency and Grant Number
Corresponding Author	Dr. Diogo Telles-Correia, Faculty of Medicine, University of Lisbon, A.v. Padre Cruz, 1649-028 Lisbon, Portugal. tellesdiogo@gmail.com
Key Words	Liver; Toxicity; Psychotropic drugs; Pharma­cokinetics; Hepatic disease
Core Tip	The liver is the organ by which the majority of substances are metabolized, including psychotropic drugs. There are several pharmacokinetic changes in end-stage liver disease that can interfere with the meta-bolization of psychotropic drugs. The evidence is insufficient for definite conclusions regarding the prevalence and severity of psychiatric drug-induced liver injury. High-risk psychotropics are not advised when there is pre-existing liver disease, and after starting a psychotropic agent in a patient with hepatic impairment, frequent liver function/lesion monitoring is advised.
Publish Date	2017-01-20 16:40
Citation	Telles-Correia D, Barbosa A, Cortez-Pinto H, Campos C, Rocha NBF, Machado S. Psychotropic drugs and liver disease: A critical review of pharmacokinetics and liver toxicity. World J Gastrointest Pharmacol Ther 2017; 8(1): 26-38
URL	http://www.wjgnet.com/2150-5349/full/v8/i1/26.htm
DOI	http://dx.doi.org/10.4292/wjgpt.v8.i1.26

Full Article (PDF)	WJGPT-8-26.pdf
Full Article (Word)	WJGPT-8-26.doc
Manuscript File	30070-Review.docx
Answering Reviewers	30070-Answering reviewers.pdf
Audio Core Tip	30070-Audio core tip.mp3
Conflict-of-Interest Disclosure Form	30070-Conflict-of-interest statement.pdf
Copyright License Agreement	30070-Copyright assignment.pdf
Non-Native Speakers of English Editing Certificate	30070-Language certificate.pdf
Peer-review Report	30070-Peer-review(s).pdf
Journal Editor-in-Chief Review Report	30070-Journal editor-in-chief review report.pdf
Scientific Misconduct Check	30070-Scientific misconduct check.pdf
Scientific Editor Work List	30070-Scientific editor work list.pdf