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Articles Published Processes
2/15/2017 11:49:00 AM | Browse: 929 | Download: 1234
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Received |
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2016-09-18 16:55 |
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Peer-Review Started |
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2016-09-19 19:04 |
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To Make the First Decision |
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Return for Revision |
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Revised |
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2016-11-16 12:57 |
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Second Decision |
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2016-12-14 18:34 |
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Accepted by Journal Editor-in-Chief |
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Accepted by Company Editor-in-Chief |
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2016-12-28 15:17 |
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Articles in Press |
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2016-12-28 15:17 |
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Publication Fee Transferred |
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Edit the Manuscript by Language Editor |
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Typeset the Manuscript |
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2017-02-12 21:57 |
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Publish the Manuscript Online |
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2017-02-15 11:49 |
| ISSN |
1948-9358 (online) |
| Open Access |
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2017. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Biochemistry & Molecular Biology |
| Manuscript Type |
Case Control Study |
| Article Title |
Association of NFKB1 gene polymorphism (rs28362491) with levels of inflammatory biomarkers and susceptibility to diabetic nephropathy in Asian Indians
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| Manuscript Source |
Invited Manuscript |
| All Author List |
Amar Gautam, Stuti Gupta, Mohit Mehndiratta, Mohini Sharma, Kalpana Singh, Om P Kalra, Sunil Agarwal and Jasvinder K Gambhir |
| Funding Agency and Grant Number |
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| Corresponding Author |
Jasvinder K Gambhir, PhD, Professor, Molecular Diagnostic Laboratory, Department of Biochemistry, University College of Medical Sciences (University of Delhi) and G.T.B. Hospital, Dilshad Garden, Delhi 110095,
India. jassigambhir@yahoo.co.in
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| Key Words |
Diabetic nephropathy; Inflammation; NFKB1 -94 ATTG ins/del polymorphism; Urinary monocyte chemoattractant protein-1; Tumor necrosis factor-alpha |
| Core Tip |
Type 2 diabetes mellitus (T2DM) is considered as long standing inflammatory disease. Diabetic nephropathy (DN) is the most common micro-vascular complication of T2DM. Pro-inflammatory cytokines like Monocyte chemoattractant protein-1 (MCP-1) and tumor necrosis factor-alpha (TNF-α) plays a crucial role in the pathogenesis of DN. Therefore we investigated -94 ins/del ATTG polymorphism in NFKB1 gene and its association with the risk of DN in Asian Indians. -94 ins/del ATTG single nucleotide polymorphism was found to increase the urinary MCP-1 and plasma TNF-α levels. Our findings open a new area of research to explore that -94 ins/del ATTG may be considered as genetic markers for early detection of diabetic patients who are at greater risk of development of nephropathy.
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| Publish Date |
2017-02-15 11:49 |
| Citation |
Gautam A, Gupta S, Mehndiratta M, Sharma M, Singh K, Kalra OP, Agarwal S, Gambhir JK. Association of NFKB1 gene polymorphism (rs28362491) with levels of inflammatory biomarkers and susceptibility to diabetic nephropathy in Asian Indians. World J Diabetes 2017; 8(2): 66-73 |
| URL |
http://www.wjgnet.com/1948-9358/full/v8/i2/66.htm |
| DOI |
http://dx.doi.org/10.4239/wjd.v8.i2.66 |
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