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Articles Published Processes
1/14/2017 10:42:00 AM | Browse: 1060 | Download: 1873
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Received |
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2016-09-15 09:34 |
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Peer-Review Started |
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2016-09-19 08:55 |
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To Make the First Decision |
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2016-10-10 12:15 |
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Return for Revision |
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2016-10-13 17:43 |
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Revised |
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2016-10-29 00:19 |
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Second Decision |
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2016-12-01 16:23 |
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Accepted by Journal Editor-in-Chief |
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Accepted by Executive Editor-in-Chief |
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2016-12-08 15:33 |
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Articles in Press |
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2016-12-08 15:34 |
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Publication Fee Transferred |
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Edit the Manuscript by Language Editor |
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Typeset the Manuscript |
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2016-12-30 16:27 |
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Publish the Manuscript Online |
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2017-01-14 10:27 |
| ISSN |
1007-9327 (print) and 2219-2840 (online) |
| Open Access |
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2017. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Gastroenterology & Hepatology |
| Manuscript Type |
Basic Study |
| Article Title |
IL23R single nucleotide polymorphisms could be either beneficial or harmful in ulcerative colitis
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| Manuscript Source |
Invited Manuscript |
| All Author List |
Sarah Fischer, Erzsébet Kövesdi, Lili Magyari, Veronika Csöngei, Kinga Hadzsiev, Béla Melegh, Péter Hegyi and Patrícia Sarlós |
| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| Hungarian Science Foundation (OTKA) |
K103983 |
| Hungarian Science Foundation (OTKA) |
K119540 |
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| Corresponding Author |
Patrícia Sarlós, MD, PhD, Division of Gastroenterology, 1st Department of Internal Medicine, University of Pécs, 12 Szigeti street, 7624 Pécs, Hungary. sarlos.patricia@pte.hu |
| Key Words |
IL23R gene; ulcerative colitis; phenotype; polymorphism; Hungarian |
| Core Tip |
IL23R gene plays important role in the development and influences the phenotype of inflammatory bowel diseases. We investigated the association of seven single nucleotide polymorphisms (SNPs) of IL23R gene with the clinical picture of ulcerative colitis (UC). Two SNPs were associated with greater colonic extension. At two SNPs, there was more frequently need for operations. Rs2201841 was found as a risk factor for the development of iron deficiency. Patients with rs10889677, therapy with azathioprine was more frequently necessary. Patients with rs10489629 SNP had lower risk for weight loss. This study demonstrated the influence of the investigated SNPs of IL23R on the phenotype of UC, confirming genetic association. |
| Publish Date |
2017-01-14 10:27 |
| Citation |
Fischer S, Kövesdi E, Magyari L, Csöngei V, Hadzsiev K, Melegh B, Hegyi P, Sarlós P. IL23R single nucleotide polymorphisms could be either beneficial or harmful in ulcerative colitis. World J Gastroenterol 2017; 23(3): 447-454 |
| URL |
http://www.wjgnet.com/1007-9327/full/v23/i3/447.htm |
| DOI |
http://dx.doi.org/10.3748/wjg.v23.i3.447 |
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