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Articles Published Processes
3/6/2017 1:27:00 PM | Browse: 1107 | Download: 2031
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Received |
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2016-09-27 09:59 |
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Peer-Review Started |
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2016-09-27 18:11 |
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To Make the First Decision |
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2016-10-28 13:19 |
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Return for Revision |
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2016-11-02 18:10 |
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Revised |
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2016-11-13 18:35 |
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Second Decision |
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2016-12-25 10:13 |
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Accepted by Journal Editor-in-Chief |
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2016-12-25 16:32 |
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Accepted by Executive Editor-in-Chief |
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2017-01-03 12:02 |
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Articles in Press |
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2017-01-03 12:02 |
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Publication Fee Transferred |
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Edit the Manuscript by Language Editor |
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Typeset the Manuscript |
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2017-02-24 15:29 |
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Publish the Manuscript Online |
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2017-03-06 13:24 |
| ISSN |
1007-9327 (print) and 2219-2840 (online) |
| Open Access |
Open-Access: This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2017. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Pathology |
| Manuscript Type |
Basic Study |
| Article Title |
Proton pump inhibitor induced collagen expression in colonocytes is associated with collagenous colitis
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| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Shiori Mori, Yui Kadochi, Yi Luo, Rina Fujiwara-Tani, Yukiko Nishiguchi, Shingo Kishi, Kiyomu Fujii, Hitoshi Ohmori and Hiroki Kuniyasu |
| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| MEXT KAKENHI |
14478268 |
| MEXT KAKENHI |
16675788 |
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| Corresponding Author |
Hiroki Kuniyasu, MD, PhD, Professor, Chairman, Department of Molecular Pathology, Nara Medical University, 840 Shijo-cho, Kashihara, Nara 634-8521, Japan. cooninh@zb4.so-net.ne.jp |
| Key Words |
proton pump inhibitor; collagenous colitis; pH; fibrosis; oxidative stress |
| Core Tip |
The main contribution of our paper is the finding of the basic mechanism of proton pump inhibitor evoking collagenous colitis with direct effects to colon epithelial cells. The collagenous colitis is a major cause of non-hemorrhagic watery diarrhea; however, the mechanism of the disease has not been fully elucidated. Our research findings show that proton pump inhibitor causes oxidative stress and collagen synthesis in colon epithelial cells, which might provide an impact to understanding pathogenesis of collagenous colitis and the side effect of proton pump inhibitor. |
| Publish Date |
2017-03-06 13:24 |
| Citation |
Mori S, Kadochi Y, Luo Y, Fujiwara-Tani R, Nishiguchi Y, Kishi S, Fujii K, Ohmori H, Kuniyasu H. Proton pump inhibitor induced collagen expression in colonocytes is associated with collagenous colitis. World J Gastroenterol 2017; 23(9): 1586-1593 |
| URL |
http://www.wjgnet.com/1007-9327/full/v23/i9/1586.htm |
| DOI |
http://dx.doi.org/10.3748/wjg.v23.i9.1586 |
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