Publication Name	World Journal of Gastroenterology
Manuscript ID	30328
Country	Belgium

Received	2016-09-27 09:32
Peer-Review Started	2016-09-28 14:32
To Make the First Decision	2016-12-19 11:29
Return for Revision	2016-12-19 16:26
Revised	2017-01-20 22:26
Second Decision	2017-03-01 11:17
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2017-03-02 17:09
Articles in Press	2017-03-02 17:09
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2017-03-15 16:11
Publish the Manuscript Online	2017-03-28 10:34

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access	This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright	© The Author(s) 2017. Published by Baishideng Publishing Group Inc. All rights reserved.
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Website	http://www.wjgnet.com

Category	Gastroenterology & Hepatology
Manuscript Type	Review
Article Title	Regulation of intestinal permeability: The role of proteases
Manuscript Source	Invited Manuscript
All Author List	Hanne Van Spaendonk, Hannah Ceuleers, Leonie Witters, Eveline Patteet, Jurgen Joossens, Koen Augustyns, Anne-Marie Lambeir, Ingrid De Meester, Joris G De Man and Benedicte Y De Winter
Funding Agency and Grant Number	Funding Agency Grant Number University of Antwerp grant GOA 2013
Corresponding Author	Benedicte Y De Winter, Professor, MD, PhD, Laboratory of Experimental Medicine and Pediatrics, Division of Gastroenterology, University of Antwerp, Universiteitsplein 1, 2610 Antwerp, Belgium. benedicte.dewinter@uantwerpen.be
Key Words	Intestinal permeability; Intestinal barrier; Tight junction; Paracellular permeability; Proteases; Proteinase-activated receptor; Protease inhibitor; Antiproteases
Core Tip	Increased intestinal permeability is a novel player in the pathophysiology of various intestinal and extra-intestinal diseases such as inflammatory bowel disease, celiac disease and type 1 diabetes. A dysregulated protease/antiproteases balance is suggested as a cause of intestinal barrier dysfunction, with a subsequent increase in permeability. Immune cells infiltrating in the lamina propria during inflammatory conditions provide a pro-inflammatory environment by the production of cytokines and proteases. Protease inhibition has therapeutic potential but more research is needed to elucidate the exact involvement of specific proteases in gut physiology and intestinal barrier function.
Publish Date	2017-03-28 10:34
Citation	Van Spaendonk H, Ceuleers H, Witters L, Patteet E, Joossens J, Augustyns K, Lambeir AM, De Meester I, De Man JG, De Winter BY. Regulation of intestinal permeability: The role of proteases. World J Gastroenterol 2017; 23(12): 2106-2123
URL	http://www.wjgnet.com/1007-9327/full/v23/i12/2106.htm
DOI	http://dx.doi.org/10.3748/wjg.v23.i12.2106

Full Article (PDF)	WJG-23-2106.pdf
Full Article (Word)	WJG-23-2106.doc
Manuscript File	30328-Review.docx
Answering Reviewers	30328-Answering reviewers.pdf
Audio Core Tip	30328-Audio core tip.mp3
Conflict-of-Interest Disclosure Form	30328-Conflict-of-interest statement.pdf
Copyright License Agreement	30328-Copyright assignment.pdf
Peer-review Report	30328-Peer-review(s).pdf
Scientific Misconduct Check	30328-Scientific misconduct check.pdf
Scientific Editor Work List	30328-Scientific editor work list.pdf