Publication Name	World Journal of Hepatology
Manuscript ID	30333
Country	United States

Received	2016-09-27 08:55
Peer-Review Started	2016-09-28 12:07
To Make the First Decision	2016-10-20 08:51
Return for Revision	2016-10-31 09:22
Revised	2016-12-04 00:00
Second Decision	2016-12-12 08:41
Accepted by Journal Editor-in-Chief	2016-12-12 09:26
Accepted by Executive Editor-in-Chief	2016-12-19 11:11
Articles in Press	2016-12-19 11:11
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2017-02-13 16:27
Publish the Manuscript Online	2017-02-17 08:32

ISSN	1948-5182 (online)
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Category	Transplantation
Manuscript Type	Meta-Analysis
Article Title	Is it time to rethink combined liver-kidney transplant in hepatitis C patients with advanced fibrosis?
Manuscript Source	Unsolicited Manuscript
All Author List	Niraj James Shah and Mark W Russo
Funding Agency and Grant Number
Corresponding Author	Niraj James Shah, MD, Assistant Professor of Medicine, Department of Medicine, Division of Digestive Diseases, the University of Mississippi Medical Center, 2500 North State Street, Jackson, MS 39216, United States. jnshah@umc.edu
Key Words	Cirrhosis/cirrhotics; Renal transplantation; Kidney transplantation; Mortality; Systematic review; Graft outcomes; Meta-analysis
Core Tip	Individuals with chronic hepatitis C with ad-vanced fibrosis and kidney failure who undergo kidney transplant alone are believed to have lower long-term survival. Surprisingly, we have only a few studies with inconsistent results. The concern about isolated-kidney-transplant alone is that the liver disease would progress to decompensated cirrhosis and liver failure in the setting of immunosuppression after kidney transplant. Earlier, interferon was associated with low virologic cure and high adverse events including graft rejection. However, with development of newer directly acting anti-virals we wish to invite our readers to reconsider the need for a combined liver-kidney transplant in hepatitis C patients with advanced fibrosis or compensated cirrhosis.
Publish Date	2017-02-17 08:32
Citation	Shah NJ, Russo MW. Is it time to rethink combined liver-kidney transplant in hepatitis C patients with advanced fibrosis? World J Hepatol 2017; 9(5): 288-292
URL	http://www.wjgnet.com/1948-5182/full/v9/i5/288.htm
DOI	http://dx.doi.org/10.4254/wjh.v9.i5.288

Full Article (PDF)	WJH-9-288.pdf
Full Article (Word)	WJH-9-288.doc
Manuscript File	30333-Review.docx
Answering Reviewers	30333-Answering reviewers.pdf
Audio Core Tip	30333-Audio core tip.mp3
Conflict-of-Interest Disclosure Form	30333-Conflict-of-interest statement.pdf
Copyright License Agreement	30333-Copyright assignment.pdf
Peer-review Report	30333-Peer-review(s).pdf
Journal Editor-in-Chief Review Report	30333-Journal editor-in-chief review report.pdf
Scientific Misconduct Check	30333-Scientific misconduct check.pdf
Scientific Editor Work List	30333-Scientific editor work list.pdf