Publication Name	World Journal of Hepatology
Manuscript ID	30377
Country	Egypt

Received	2016-09-29 17:27
Peer-Review Started	2016-09-30 17:39
To Make the First Decision	2016-12-27 18:26
Return for Revision	2016-12-29 11:58
Revised	2017-01-06 07:03
Second Decision	2017-03-02 16:13
Accepted by Journal Editor-in-Chief	2017-03-02 22:58
Accepted by Company Editor-in-Chief	2017-03-13 11:29
Articles in Press	2017-03-13 11:29
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2017-03-17 17:28
Publish the Manuscript Online	2017-03-24 09:18

ISSN	1948-5182 (online)
Open Access	This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright	© The Author(s) 2017. Published by Baishideng Publishing Group Inc. All rights reserved.
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Category	Gastroenterology & Hepatology
Manuscript Type	Case Control Study
Article Title	Annexin A2 as a biomarker for hepatocellular carcinoma in Egyptian patients
Manuscript Source	Invited Manuscript
All Author List	Mohamed K Shaker, Hanzada I Abdel Fattah, Ghada S Sabbour, Iman F Montasser, Sara M Abdelhakam, Eman El Hadidy, Rehab Yousry and Ahmed K El Dorry
Funding Agency and Grant Number
Corresponding Author	Sara M Abdelhakam, MD, Assistant Professor of Tropical Medicine, Department of Tropical Medicine, Faculty of Medicine, Ain Shams University, Khalifa El-Maamon Street, Abbassia, Cairo 11341, Egypt. saratropical@yahoo.com
Key Words	Hepatocellular carcinoma; Hepatitis C virus; annexin A2; Alpha-fetoprotein; Tumor markers
Core Tip	Thirty percent of hepatocellular carcinoma (HCC) patients present with normal serum alpha feto-protein, which highlights the need for new biomarkers for HCC. In the present study, a highly significant diffe-rence was observed among patients with HCC and chronic liver disease as well as controls with regard to serum annexin A2 (ANXA2) levels (130, IQR 15-240; 15, IQR 15-17; and 17, IQR 15-30 ng/ml, respectively). The area under the curve of ANXA2 was 0.865; the cut-off value was 18 ng/mL with a diagnostic sensitivity of 74% and specificity of 88%. Thus, ANXA2 may serve as a useful biomarker for the early detection of HCC.
Publish Date	2017-03-24 09:18
Citation	Shaker MK, Abdel Fattah HI, Sabbour GS, Montasser IF, Abdelhakam SM, El Hadidy E, Yousry R, El Dorry AK. Annexin A2 as a biomarker for hepatocellular carcinoma in Egyptian patients. World J Hepatol 2017; 9(9): 469-476
URL	http://www.wjgnet.com/1948-5182/full/v9/i9/469.htm
DOI	http://dx.doi.org/10.4254/wjh.v9.i9.469

Full Article (PDF)	WJH-9-469.pdf
Full Article (Word)	WJH-9-469.doc
Manuscript File	30377-Review.docx
Answering Reviewers	30377-Answering reviewers.pdf
Audio Core Tip	30377-Audio core tip.mp3
Biostatistics Review Certificate	30377-Biostatistics statement.pdf
Clinical Trial Registration Statement	30377-Clinical trial registration statement.pdf
Conflict-of-Interest Disclosure Form	30377-Conflict-of-interest statement.pdf
Copyright License Agreement	30377-Copyright assignment.pdf
Signed Informed Consent Form(s) or Document(s)	30377-Clinical trial registration statement.pdf
Institutional Review Board Approval Form or Document	30377-Institutional review board statement.pdf
Non-Native Speakers of English Editing Certificate	30377-Language certificate.pdf
Peer-review Report	30377-Peer-review(s).pdf
Journal Editor-in-Chief Review Report	30377-Journal editor-in-chief review report.pdf
Scientific Misconduct Check	30377-Scientific misconduct check.pdf
Scientific Editor Work List	30377-Scientific editor work list.pdf