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3/24/2017 9:18:00 AM | Browse: 264 | Download: 518
Publication Name World Journal of Hepatology
Manuscript ID 30377
Country of Manuscript Source Egypt
2016-09-29 17:27
Peer-Review Started
2016-09-30 17:39
To Make the First Decision
2016-12-27 18:26
Return for Revision
2016-12-29 11:58
2017-01-06 07:03
Second Decision
2017-03-02 16:13
Accepted by Journal Editor-in-Chief
2017-03-02 22:58
Accepted by Company Editor-in-Chief
2017-03-13 11:29
Articles in Press
2017-03-13 11:29
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript
2017-03-17 17:28
Publish the Manuscript Online
2017-03-24 09:18
ISSN 1948-5182 (online)
Open Access This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright © The Author(s) 2017. Published by Baishideng Publishing Group Inc. All rights reserved.
Article Reprints For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
Permissions For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher Baishideng Publishing Group Inc, 7901 Stoneridge Drive, Suite 501, Pleasanton, CA 94588, USA
Website http://www.wjgnet.com
Specialty Gastroenterology and Hepatology
Manuscript Type Case Control Study
Article Title Annexin A2 as a biomarker for hepatocellular carcinoma in Egyptian patients
Manuscript Source Invited Manuscript
All Author List Mohamed K Shaker, Hanzada I Abdel Fattah, Ghada S Sabbour, Iman F Montasser, Sara M Abdelhakam, Eman El Hadidy, Rehab Yousry and Ahmed K El Dorry
Funding Agency and Grant Number
Correspondence To Sara M Abdelhakam, MD, Assistant Professor of Tropical Medicine, Department of Tropical Medicine, Faculty of Medicine, Ain Shams University, Khalifa El-Maamon Street, Abbassia, Cairo 11341, Egypt. saratropical@yahoo.com
Keywords Hepatocellular carcinoma; Hepatitis C virus; annexin A2; Alpha-fetoprotein; Tumor markers
Core Tip Thirty percent of hepatocellular carcinoma (HCC) patients present with normal serum alpha feto-protein, which highlights the need for new biomarkers for HCC. In the present study, a highly significant diffe-rence was observed among patients with HCC and chronic liver disease as well as controls with regard to serum annexin A2 (ANXA2) levels (130, IQR 15-240; 15, IQR 15-17; and 17, IQR 15-30 ng/ml, respectively). The area under the curve of ANXA2 was 0.865; the cut-off value was 18 ng/mL with a diagnostic sensitivity of 74% and specificity of 88%. Thus, ANXA2 may serve as a useful biomarker for the early detection of HCC.
Publish Date 2017-03-24 09:18
Citation Shaker MK, Abdel Fattah HI, Sabbour GS, Montasser IF, Abdelhakam SM, El Hadidy E, Yousry R, El Dorry AK. Annexin A2 as a biomarker for hepatocellular carcinoma in Egyptian patients. World J Hepatol 2017; 9(9): 469-476
Url http://www.wjgnet.com/1948-5182/full/v9/i9/469.htm
DOI http://dx.doi.org/10.4254/wjh.v9.i9.469
Full Article (PDF) WJH-9-469.pdf
Full Article (Word) WJH-9-469.doc
Revised Manuscript 30377-Review.docx
Peer-review Report 30377-Peer-review(s).pdf
Journal Editor-in-Chief Review Report 30377-Journal editor-in-chief review report.pdf
Answering Reviewers 30377-Answering reviewers.pdf
Scientific Misconduct Check 30377-Scientific misconduct check.pdf
Scientific Editor Work List 30377-Scientific editor work list.pdf
Audio Core Tip 30377-Audio core tip.mp3
Biostatistics Review Certificate 30377-Biostatistics statement.pdf
Clinical Trial Registration Statement 30377-Clinical trial registration statement.pdf
Conflict-of-Interest Disclosure Form 30377-Conflict-of-interest statement.pdf
Copyright License Agreement 30377-Copyright assignment.pdf
Data Sharing Statement 30377-Data sharing statement.pdf
Signed Informed Consent Form(s) or Document(s) 30377-Clinical trial registration statement.pdf
Institutional Review Board Approval Form or Document 30377-Institutional review board statement.pdf
Non-Native Speakers of English Editing Certificate 30377-Language certificate.pdf
Scientific Research Process 30377-Scientific research process.pdf