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4/17/2017 7:22:19 PM | Browse: 419 | Download: 519
Publication Name World Journal of Orthopedics
Manuscript ID 30613
Country/Territory United States
Received
2016-10-10 10:31
Peer-Review Started
2016-10-11 09:31
To Make the First Decision
2016-11-30 08:49
Return for Revision
2016-11-30 12:20
Revised
2016-12-11 20:03
Second Decision
2016-12-20 15:45
Accepted by Journal Editor-in-Chief
2016-12-21 15:30
Accepted by Company Editor-in-Chief
2017-01-03 15:19
Articles in Press
2017-01-03 15:19
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript
2017-04-10 14:12
Publish the Manuscript Online
2017-04-17 19:22
ISSN 2218-5836 (online)
Open Access This is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright © The Author(s) 2017. Published by Baishideng Publishing Group Inc. All rights reserved.
Article Reprints For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
Permissions For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website http://www.wjgnet.com
Category Orthopedics
Manuscript Type Observational Study
Article Title T1ρ/T2 mapping and histopathology of degenerative cartilage in advanced knee osteoarthritis
Manuscript Source Invited Manuscript
All Author List Benjamin S Kester, Philip M Carpenter, Hon J Yu, Taiki Nozaki, Yasuhito Kaneko, Hiroshi Yoshioka and Ran Schwarzkopf
Funding Agency and Grant Number
Funding Agency Grant Number
National Center for Research Resources and the National Center for Advancing Translational Sciences, National Institutes of Health UL1 TR000153
Corresponding author Benjamin S Kester, MD, Division of Adult Reconstruction, Department of Orthopaedics, NYU Langone Medical Center Hospital for Joint Diseases, 301 E 17th St, New York, NY 10003, United States. benjamin.kester@nyumc.org
Keywords T1rho; Osteoarthritis; Magnetic resonance imaging; Cartilage; Knee
Core Tip Magnetic resonance images of eleven healthy knees and five knees with advanced osteoarthritis (OA) were studied using T1ρ and T2 mapping. Histopathologic samples were also taken from the five osteoarthritic knees following total knee arthroplasty. Our results indicate that even though cartilage is morphologically normal or near normal, cartilage degenerative changes exist in advanced OA patients. This suggests that normal thickness cartilage or mild cartilage thinning in the advanced OA knee demonstrates depletion of proteoglycan or collagen content compared with similar appearing cartilage in young healthy knees. These early changes can be detected with T2 and T1ρ MRI techniques.
Publish Date 2017-04-17 19:22
Citation Kester BS, Carpenter PM, Yu HJ, Nozaki T, Kaneko Y, Yoshioka H, Schwarzkopf R. T1ρ/T2 mapping and histopathology of degenerative cartilage in advanced knee osteoarthritis. World J Orthop 2017; 8(4): 350-356
Url http://www.wjgnet.com/2218-5836/full/v8/i4/350.htm
DOI http://dx.doi.org/10.5312/wjo.v8.i4.350
Full Article (PDF) WJO-8-350.pdf
Full Article (Word) WJO-8-350.doc
Manuscript File 30613-Review.docx
Answering Reviewers 30613-Answering reviewers.pdf
Audio Core Tip 30613-Audio core tip.aiff
Biostatistics Review Certificate 30613-Biostatistics statement.pdf
Conflict-of-Interest Disclosure Form 30613-Conflict-of-interest statement.pdf
Copyright License Agreement 30613-Copyright assignment.pdf
Data Sharing Statement 30613-Data sharing statement.pdf
Approved Grant Application Form(s) or Funding Agency Copy of any Approval Document(s) 30613-Grant application form(s).pdf
Signed Informed Consent Form(s) or Document(s) Informed_Consent_Statement_20161010013413.docx
Institutional Review Board Approval Form or Document 30613-Institutional review board statement.pdf
Scientific Research Process 30613-Scientific research process.pdf
Peer-review Report 30613-Peer-review(s).pdf
Journal Editor-in-Chief Review Report 30613-Journal editor-in-chief review report.pdf
Scientific Misconduct Check 30613-Scientific misconduct check.pdf
Scientific Editor Work List 30613-Scientific editor work list.pdf