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Articles Published Processes
4/17/2017 7:22:19 PM | Browse: 1298 | Download: 2262
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Received |
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2016-10-10 10:31 |
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Peer-Review Started |
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2016-10-11 09:31 |
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To Make the First Decision |
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2016-11-30 08:49 |
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Return for Revision |
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2016-11-30 12:20 |
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Revised |
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2016-12-11 20:03 |
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Second Decision |
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2016-12-20 15:45 |
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Accepted by Journal Editor-in-Chief |
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2016-12-21 15:30 |
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Accepted by Executive Editor-in-Chief |
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2017-01-03 15:19 |
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Articles in Press |
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2017-01-03 15:19 |
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Publication Fee Transferred |
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Edit the Manuscript by Language Editor |
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Typeset the Manuscript |
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2017-04-10 14:12 |
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Publish the Manuscript Online |
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2017-04-17 19:22 |
| ISSN |
2218-5836 (online) |
| Open Access |
This is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2017. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Orthopedics |
| Manuscript Type |
Observational Study |
| Article Title |
T1ρ/T2 mapping and histopathology of degenerative cartilage in advanced knee osteoarthritis
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| Manuscript Source |
Invited Manuscript |
| All Author List |
Benjamin S Kester, Philip M Carpenter, Hon J Yu, Taiki Nozaki, Yasuhito Kaneko, Hiroshi Yoshioka and Ran Schwarzkopf |
| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| National Center for Research Resources and the National Center for Advancing Translational Sciences, National Institutes of Health |
UL1 TR000153 |
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| Corresponding Author |
Benjamin S Kester, MD, Division of Adult Reconstruction, Department of Orthopaedics, NYU Langone Medical Center Hospital for Joint Diseases, 301 E 17th St, New York, NY 10003, United States. benjamin.kester@nyumc.org |
| Key Words |
T1rho; Osteoarthritis; Magnetic resonance imaging; Cartilage; Knee |
| Core Tip |
Magnetic resonance images of eleven healthy knees and five knees with advanced osteoarthritis (OA) were studied using T1ρ and T2 mapping. Histopathologic samples were also taken from the five osteoarthritic knees following total knee arthroplasty. Our results indicate that even though cartilage is morphologically normal or near normal, cartilage degenerative changes exist in advanced OA patients. This suggests that normal thickness cartilage or mild cartilage thinning in the advanced OA knee demonstrates depletion of proteoglycan or collagen content compared with similar appearing cartilage in young healthy knees. These early changes can be detected with T2 and T1ρ MRI techniques. |
| Publish Date |
2017-04-17 19:22 |
| Citation |
Kester BS, Carpenter PM, Yu HJ, Nozaki T, Kaneko Y, Yoshioka H, Schwarzkopf R. T1ρ/T2 mapping and histopathology of degenerative cartilage in advanced knee osteoarthritis. World J Orthop 2017; 8(4): 350-356 |
| URL |
http://www.wjgnet.com/2218-5836/full/v8/i4/350.htm |
| DOI |
http://dx.doi.org/10.5312/wjo.v8.i4.350 |
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