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Articles Published Processes
2/26/2017 6:20:00 PM | Browse: 1237 | Download: 2648
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Received |
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2016-10-12 10:07 |
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Peer-Review Started |
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2016-10-13 08:39 |
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To Make the First Decision |
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2016-12-02 08:18 |
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Return for Revision |
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2016-12-02 11:05 |
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Revised |
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2016-12-20 17:18 |
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Second Decision |
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2017-01-16 13:58 |
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Accepted by Journal Editor-in-Chief |
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Accepted by Executive Editor-in-Chief |
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2017-01-17 16:57 |
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Articles in Press |
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2017-01-17 16:58 |
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Publication Fee Transferred |
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Edit the Manuscript by Language Editor |
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2017-01-21 09:16 |
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Typeset the Manuscript |
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2017-02-16 09:22 |
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Publish the Manuscript Online |
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2017-02-26 18:20 |
| ISSN |
1007-9327 (print) and 2219-2840 (online) |
| Open Access |
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2017. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Gastroenterology & Hepatology |
| Manuscript Type |
Basic Study |
| Article Title |
Hydrogen-rich water protects against inflammatory bowel disease in mice by inhibiting endoplasmic reticulum stress and promoting heme oxygenase-1 expression
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| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Nai-Ying Shen, Jian-Bin Bi, Jing-Yao Zhang, Si-Min Zhang, Jing-Xian Gu, Kai Qu and Chang Liu |
| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| Project of Innovative Research Team for Key Science and Technology in Shaanxi Province |
2013KCJ-23 |
| Fundamental Research Funds for the Central Universities |
1191320114 |
| National Nature Science Foundation of China |
81601672 |
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| Corresponding Author |
Chang Liu, MD, PhD, Department of Hepatobiliary Surgery, The First Affiliated Hospital of Xi’an Jiaotong University, No. 277 Yanta West Road, Xi’an 710061, Shaanxi Province, China. liuchangdoctor@163.com |
| Key Words |
Hydrogen; Inflammatory bowel disease; Oxidative stress; Endoplasmic reticulum stress; Heme oxygenase-1 |
| Core Tip |
Inflammatory bowel disease (IBD) is a chronic and relapsing disease primarily caused by the production of pro-inflammatory cytokines and leukocyte infiltration, resulting in structural and functional damage to the bowel. Hydrogen has obvious anti-oxidative and anti-inflammatory effects. We launched a study to investigate the protective role of hydrogen-rich water (HRW) on IBD in mice. The present study found that HRW has a significant therapeutic potential in IBD by inhibiting inflammatory factors, oxidative stress and endoplasmic reticulum stress and by up-regulating heme oxygenase-1 expression. |
| Publish Date |
2017-02-26 18:20 |
| Citation |
Shen NY, Bi JB, Zhang JY, Zhang SM, Gu JX, Qu K, Liu C. Hydrogen-rich water protects against inflammatory bowel disease in mice by inhibiting endoplasmic reticulum stress and promoting heme oxygenase-1 expression. World J Gastroenterol 2017; 23(8): 1375-1386 |
| URL |
http://www.wjgnet.com/1007-9327/full/v23/i8/1375.htm |
| DOI |
http://dx.doi.org/10.3748/wjg.v23.i8.1375 |
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